重度子痫前期患者分娩前后血清VEGF浓度的改变  

Changes of VEGF between pre-and post-delivery in patients with severe preeclampsia

作　　者：王燕云[1] 陈宝丽[1] 李桂荣[1] 宋海澄[2] 左金玲[3] 

机构地区：[1]唐山市妇幼保健院妇产科,河北唐山063000 [2]河北联合大学附属开滦医院,河北唐山063000 [3]河北联合大学,河北唐山063000

出　　处：《中国现代医学杂志》2012年第7期48-51,共4页China Journal of Modern Medicine

基　　金：2009年唐山市科技支撑项目(No:09130221a)

摘　　要：目的探讨子痫前期患者外周血中VEGF在分娩前后的变化以及与临床症状的相关性。方法采用ELISA法检测50例重度子痫前期患者和年龄、孕周匹配的50例正常对照者分娩前和分娩后72h外周血中VEGF的浓度,对比分析重度子痫前期患者外周血VEGF水平分娩前后的改变以及分娩前与临床指标的相关性。结果重度子痫前期组产前VEGF水平明显高于正常对照组(P<0.01);分娩后72h重度子痫前期组的VEGF水平迅速回落至近似正常对照组水平(P<0.001);正常对照组分娩前后以及与重度子痫前期组分娩后比较VEGF水平差异均无显著性(P>0.05)。相关分析发现重度子痫前期组血清VEGF水平与收缩压、舒张压和24h尿蛋白定量、ALT和AST呈正相关关系,而与血清钙呈负相关关系,统计学分析差异均具有显著性。正常对照组中VEGF水平与临床资料及实验室数据之间统计学分析均未见相关性。结论重度子痫前期母体循环中VEGF浓度显著增加,而于分娩后72h迅速下降,并且与其临床指标相关,提示VEGF在重度子痫前期疾病发病中起着重要作用。【Objective】 To study the changes of VEGF concentration in peripheral blood of patients with severe preeclampsia between prenatal and postnatal,and the correlation with the clinical symptoms.【Method】 50 patients with severe preeclampsia and 50 normal pregnant women had blood collected respectively at pre-delivery and 72 hours after delivery,serum levels of VEGF were detected by ELISA.【Result】 Pre-delivery the serum VEGF concentration in the severe preeclampsia group greater than normal group（P〈 0.01）.Serum VEGF levels of severe preeclampsia fell rapidly to the level of normal group within 72 hours（P 0.001）.There was no significant difference between the serum VEGF level in the severe preeclampsia group of Post-delivery and both pre-and post-delivery in normal group（P〉0.05）.VEGF levels of severe preeclampsia group has positive correlation to SBP,DBP,24-hour urinary protein quantitative,ALT and AST,but has negative correlation to serumcalcium.Correlation analysis in normal group hasn＇t significant correlation.【Conclusion】 The level of VEGF in peripheral blood of patients with severe preeclampsia increased significantly,fell rapidly to normal within 72 hours,and it was related to the clinical date,VEGF maybe plays an important role in pathogenesis of severe preeclampsia.

关 键 词：子痫前期 重度 VEGF 血清 

分 类 号：R714.25[医药卫生—妇产科学]