外科感染常见革兰氏阴性杆菌的分布及其耐药性分析  

Analysis of the distribution and drug resistance of frequent Gram-Negative bacillus in surgical infection

作　　者：沈映冰[1] 徐鸿绪[2] 徐慧得 黄健宇[2] 杜玲[2] 赖在真[2] 

机构地区：[1]中山大学附属第六医院药剂科,510655 [2]中山大学附属第一医院东山院区检验科 [3]民航广州医院外科

出　　处：《中国现代药物应用》2012年第5期5-6,共2页Chinese Journal of Modern Drug Application

摘　　要：目的了解外科感染常见革兰氏阴性杆菌的分布及其对常用抗生素的耐药性,为指导临床用药提供依据。方法回顾性分析909例外科住院并发生医院感染患者的革兰氏阴性杆菌及其药物敏感试验结果。结果 909株革兰氏阴性杆菌中,大肠埃希菌占52.70%(479/909),铜绿假单胞菌占18.15%(165/909),肺炎克雷伯菌占16.61%(151/909),阴沟肠杆菌占6.38%(58/909),鲍曼不动杆菌占6.16%(56/909)。各种革兰氏阴性杆菌均产生了不同程度的耐药性,亚胺培南、美洛培南、阿米卡星的耐药率0～26.9%,具有较好抗菌效果。结论外科感染较为严重,临床应根据药敏试验结果合理使用抗生素,减少外科医院感染的发生和耐药菌株的产生。Objective To guide the clinical drug use by studying the distribution of frequent Gram-Negative bacillus in surgical infection and drug resistance of frequently used antibiotic.Methods The distribution and drug resistance result of Gram-Negative bacillus of 909 surgical patients in hospital with nosocomial infection were investigated retrospectively.Results Among the 909 strains of Gram-Negative bacillus,there were 479 strains of Escherichia coli（52.70%）,165 strains of Pseudomonas aeruginosa（18.15%）,151 strains of Klebsiella pneumoniae（16.61%）,58 strains of Enterobacter cloacae（6.38%）,and 56 strains of baumanii（6.16%）.The drug resistance of all kinds of the Gram-Negative bacillus was in various degrees.The rate of drug resistance of imipenem,Meropenem,Amikacin was from 0 to 26.9%,showing better antibacterial effects.Conclusion Since the surgical infection is severe,rational use of antibiotics should be carried out according to the drug sensitivity,to decrease surgical infection and the appearance of drug-resistant strain.

关 键 词：外科感染 病原菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]