超敏C-反应蛋白和胆固醇/高密度脂蛋白胆固醇比值联合测定在心血管疾病中的应用  

Application of determination of serum high-sensitivity C-reactive protein and ration of total cholesterol to HDL-cholesterol in cardiovascular disease

作　　者：张昌莲[1] 邹洪胜 

机构地区：[1]山东泰山医学院附属荣成市人民医院检验科,264300

出　　处：《中国现代药物应用》2012年第6期15-16,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨超敏C-反应蛋白(hs-CRP)和胆固醇(TG/HDL-C)在心血管疾病中的应用。方法超敏C-反应蛋白的测定采用胶乳比浊法,总胆固醇/高密度脂蛋白胆固醇的测定,分别采用氧化酶法和一步法。结果 hs-CRP、TC/HDL-C在高血压组、冠心病组(CAD)和急性心肌梗死组(AMI)与健康对照组比较,均显著升高(P<0.01)。而且急性心肌梗死组显著高于冠心病组(P<0.01),冠心病组又高于高血压组(P<0.05)。结论 hs-CRP浓度和心血管疾病及其病变程度明显相关,且联合检测hs-CRP和TC/HDL-C可提高心血管疾病的预测及危险程度的评估。Objective To investigate the role of high-sensitivity C-reactive protein（hs-CRP）and ratio of total cholestcrol to HDL-choleserol （TC/HDL-C） in caediovascular disease.Methods Hs-CRP was determined by latex-enhanced immunoturbidimetric assay,TC and HDL-C was determined by enzyme methods and homogeneous method.Results The level of hs-CRP and TC/HDL-C in patients were significantly higher than in the controls.The level of hs-CRPand TC/HDL-C in active myotardial infaction （AMI） was significantly higher than in the coronary artery disease （CAD）.The level of hs-CRP and TC/HDL-C in CAD was significantly higher than in hypcrtensiv patient.Conclusion hs-CRP is strongly associated with cardiovascular disease.It is the stronger risk assessment and predictor of cardiovascular using both hs-CRP and TC/HDL-C ratio.

关 键 词：超敏C-反应蛋白 胆固醇/高密度脂蛋白胆固醇 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]