长期铝暴露对大鼠肝脏功能的影响  

Effects of long-term aluminum exposure on liver function in rats

作　　者：李艳飞[1] 赵汉嵩[1] 罗继龙[1] 于鸿祥[1] 王明河[1] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030

出　　处：《中国兽医杂志》2012年第3期12-14,共3页Chinese Journal of Veterinary Medicine

基　　金：黑龙江省教育厅科学技术研究项目(12511028);国家自然科学基金项目(31172375)

摘　　要：旨在探讨长期铝暴露对大鼠肝脏损伤及其功能的影响,为防制其对动物肝脏器官的危害提供理论依据。48只4周龄雄性Wistar大鼠随机分为4组,分别于饮水中添加0,64.18,128.36,256.72mg/kg体重AlCl3.6H2O溶液建立长期铝暴露大鼠模型,试验期120d。断头处死大鼠,检测血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性及血清和肝脏中谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果表明,随染铝剂量的增加,各染铝组血清ALT、AST活性及肝脏MDA含量显著高于对照组(P<0.01、P<0.05);染铝组肝脏GSH-PX活性显著低于对照组(P<0.01),SOD活性呈先升高后下降趋势,低剂量组高于对照组,高剂量组显著低于对照组(P<0.01)。说明长时间铝暴露可增强肝脏脂质过氧化反应,降低抗氧化能力,引发氧化损伤,进而影响肝脏功能。To investigate effects of chronically administered aluminum on damage and function of liver in rats.Forty-eight male Wistar rats（four-week-old） were divided into four groups： experimental groups with aluminum administered chronically at 64.18,128.36,256.72 mg/kg body weight,and the control group with distilled water.The experiment lasted for 120 days.Activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-PX） and concentrations of malondialdehyde（MDA） in serum and liver as well as Serum alanine transarninase（ALT） and aspartate aminotransferase（AST） activities were determined in all groups.The results showed that the activities of ALT,AST in serum and the concentrations of MDA in liver of the aluminum groups were significantly increased compared to that of controls（P0.01,P0.05）.The activities of GSH-PX and SOD of the high-dose aluminum group were significantly lower than those in control group（P0.01）.These results indicate that long-term aluminum exposure enhances liver lipid peroxidation and inhibits antioxidative activity and injures the function of liver.

关 键 词：长期铝暴露 大鼠 肝脏功能 

分 类 号：S852.23[农业科学—基础兽医学]