感兴趣区设置方法对磁共振R2^＊值无创评估铁过载肝脏铁含量的影响  

Comparative study of MRI R2^＊ with different ROI measurement in iron-overloaded liver

作　　者：胡粟[1] 胡春洪[1] 张京刚[1] 张敏鸽[1] 王芳芳[1] 邢建明[1] 陈剑华[1] 

机构地区：[1]苏州大学附属第一医院影像中心,江苏苏州215006

出　　处：《磁共振成像》2012年第1期44-47,共4页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的比较不同ROI设置方法对定量评估铁过载家兔模型肝脏铁含量的差异。方法将32只大白兔随机分为4组,三个实验组每周注射铁剂一次。之后对所有实验兔进行MRR2-StarMap数据采集和铁含量分析。由两名放射科医师分别采用全肝ROI和设置多个小的ROI求平均值两种方法测得肝脏的R2*值。结果两种ROI选取方法在不同观察者之间均存在较好的一致性(P>0.05,ICC=0.99)。全肝ROI法所测得的R2*值较小ROI平均值法所测者偏低(P<0.05)。结论磁共振-R2*对肝过载铁含量的分析,全肝ROI测量较小ROI测量更可靠。Objective： To compare the differences of two kinds of ROI measurements of MRI liver R2＊ with iron overload, Materials and methods： Thirty-two adult healthy New Zealand rabbits were randomly divided into 4 groups, with 3 groups received intravenous injection of Iron Sucrose with different concentrations every 1 week for 4 weeks. After liver scan was performed by 3.0T MR scanner with 2D MFGRE sequence, the animals were sent for LIC assessment immediately. The R26＊ value were measured on R2^＊ Map with whole liver and small region-of interest （ROI） selection by 2 observers, independently. The R2^＊ value was compared between intra- and inter-observer; from the whole liver and the ROI, respectively. Results： The data from 2 types of measurement was consistent （P〉0.05, ICC=0.99）. The R2^＊ value measured from the whole liver was smaller than that of ROI selection （P〈0.05）. Conclusion： To analyze the over-loaded liver by MR1 R2^＊, the whole liver measurement is superior to the ROI positioning.

关 键 词：感兴趣区 R2*值 磁共振成像 铁过载 

分 类 号：R445.2[医药卫生—影像医学与核医学] R333.4[医药卫生—诊断学]