SPF级和野生布氏田鼠血生化指标的比较分析  

Comparison of blood biochemical indexes between specific pathogen-free Brandt′s vole and Brandt′s vole captured from wild population

作　　者：施海霞[1] 潘思丹[1] 梁虹[1] 宋铭晶[1] 

机构地区：[1]中国医学科学院医学实验动物研究所北京协和医学院比较医学中心卫生部人类疾病比较医学重点实验室,北京100021

出　　处：《中国卫生检验杂志》2012年第3期420-421,424,共3页Chinese Journal of Health Laboratory Technology

基　　金：国家科技支撑计划课题(2009BAI83B01)课题资助

摘　　要：目的:检测布氏田鼠的血生化指标,比较布氏田鼠无特定病原体级(specific pathogen-free,SPF)封闭群和实验室驯育野生种群之间该指标的差异。方法:分别测定4月龄野生布氏田鼠和SPF级封闭群内布氏田鼠的25项血生化指标,每个种群各抽样16只个体,雌雄各半。结果:实验室开放环境饲养的野生布氏田鼠的谷丙转氨酶(ALT)、谷草转氨酶(AST)的值均显著高于SPF级布氏田鼠,部分血生化指标不同性别之间差异较大。结论:在一定程度上,布氏田鼠体内外的微生物控制状况影响该动物的血生化指标。Objective： To compare the differences of blood biochemical indexes between Brandt′s voles from specific pathogen-free closed colony and wild population.Methods： 16 individuals（male∶female=1∶1） of 4-month-old Brandt′s vole were chosen from pathogen-free closed colony and wild population respectively.Each individual was taken blood and tested 25 blood biochemical indexes.Results： Brandt′s vole captured in wild population and raised in open environment had higher value of ALT and AST than the Brandt′s vole taken from specific pathogen-free closed colony and raised in the barrier.There were great differences of some blood biochemical indexes between male and female individuals of Brandt′s voles also.Conclusion： To some content,the value of blood biochemical indexes of Brandt′s vole can be affected by the microorganism control level inside and outside the species.

关 键 词：布氏田鼠 血生化指标 无特定病原体 

分 类 号：Q95-331[生物学—动物学]