Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells  

作　　者：Yan Zhang Si Wang Xiuxia Wang Shangying Liao Yujian Wu Chunsheng Han 

机构地区：[1]State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Graduate School of Chinese Academy of Sciences, Beijing100049, China

出　　处：《Cell Research》2012年第4期773-776,共4页细胞研究（英文版）

基　　金：Acknowledgments We thank Dr Hiroshi Kubota （University of Pennsylvania School of Veterinary Medicine, USA） for his kind help in setting up mSPG culture through E-mail communications. This study was supported by the National Basic Research Program of China （2006CB944004） and the National Natural Science Foundation of China （30300182, 30871406）.

摘　　要：Dear Editor, The in vitro propagation （IVP） of animal spermatogonial stem cells （SSCs） provides materials for studying the mechanism of spermatogenesis and for developing novel animal transgenesis and human therapy. The IVP of SSCs is reported to be promoted by exogenous growth factors, among which the glial cell-derived neurotrophic factor （GDNF） has been recognized as the single essential one [1, 2]. FGF2,

关 键 词：精原干细胞 胶质细胞源性神经营养因子 内源性 增殖 小鼠 培养 SSCS 精子发生 

分 类 号：Q954.434[生物学—动物学] Q421