血清和胆汁CA19-9联合检测对诊断胆道良恶性病变的价值  

VALUE OF BILE AND SERUM CA19-9 AND CEA IN DIAGNOSING BILIARY TRACT CARCINOMA

作　　者：秦兴雷[1] 李志强 石景森[3] 张练[1] 王作仁[3] 王林[3] 

机构地区：[1]河南省洛阳市中心医院肝胆外科,洛阳471009 [2]河南省商丘市人民医院普外科,商丘476000 [3]西安医科大学第一附属医院肝胆外科,西安710061

出　　处：《中国普外基础与临床杂志》2000年第3期161-163,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨CA19 9对胆道良恶性病变的诊断价值。方法　采用RIA联合检测经手术及病理证实的胆道恶性肿瘤 3 5例 ,胆道良性病变 92例及正常健康人 15例胆汁和血清中CA19 9及CEA水平。结果　血清CA19 9的敏感性、特异性分别为 80 .0 0 %和 85 .11% ,血清CEA的相应指标分别为 68.5 7%和 82 .97%。胆汁CA19 9含量的分界值为 12 0 0 0kU/L ,其敏感性、特异性分别为 85 .71%和 73 .91%。胆汁CEA水平分界值为 480 μg/L ,其相应指标分别为5 7.14 %和 77.17%。胆汁CA19 9及CEA含量的假阳性率分别为 2 6.0 9%和 2 2 .83 %。结论　CA19 9是诊断胆管癌是否被彻底切除 ,以及监测该病治疗反应有效的肿瘤标志物。Objective To evaluate the value of bile and serum CA19 9 in diagnosing biliary tract carcinoma. Methods Bile and serum CA19 9 and CEA were determined by radioimmunoassay (RIA). Results The dividing value of bile CA19 9 is 12 000 kU/L, and its sensitivity and specificity were 85.71%, 73.91% respectively. The dividing value of bile CEA is 480 μg/L, and its corresponding indexes were 57.14% and 77.17%. The false positive rate of bile CA19 9 and CEA were 26.09% and 22.83%. Serum CA19 9 sensitivity, specificity were 80.00% and 85.11%; the corresponding indexes of serum CEA were 68.57% and 82.97%. Conclusion CA19 9 is an effective tumor marker in diagnosing, deciding whether the tumor has been radically resected and in monitoring its response to the treatment.

关 键 词：胆管肿瘤 胆道良性病变 糖链抗原19-9 癌胚抗原 

分 类 号：R446[医药卫生—诊断学]