激素替代治疗对绝经后妇女凝血功能的影响  

Effect of Hormone Replacement Therapy on Coagulation Function in Postmenopausal Women

作　　者：叶元华[1] 高萍[1] 郭新华[1] 陈士杰 

机构地区：[1]青岛大学医学院附属医院妇产科,266003

出　　处：《中华妇产科杂志》2000年第5期285-287,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨激素替代治疗 (HRT)对绝经后妇女凝血功能的影响。方法　将 5 2例绝经后妇女分为 3组 :安慰剂组 (口服维生素C) 10例 ;雌激素组 (单纯服用雌激素 ) 19例 ;雌孕激素组 (雌孕激素合用 ) 2 3例。并以 2 0例绝经前妇女作为对照组。测定HRT前、治疗 3个月及 6个月后凝血酶原时间 (PT)、活化部分凝血激酶时间 (APTT)、纤维蛋白原 (FIB)、抗凝血酶Ⅲ (ATⅢ )、蛋白S及蛋白C的变化。结果　绝经后妇女HRT前FIB水平明显高于对照组。安慰剂组用药前后各凝血参数变化差异均无显著性。雌激素组及雌孕激素组应用HRT 3个月后 ,FIB及蛋白S明显降低 ,6个月后FIB降低更明显 ,而蛋白S恢复至近治疗前水平。雌激素组与雌孕激素组比较 ,HRT前、后各凝血参数变化差异均无显著性。结论　HRT可明显降低绝经后妇女FIB水平。Objective To study the effect of hormone replacement therapy (HRT) on coagulation function in postmenopausal women. Methods Fifty two postmenopausal women were divided into three groups: placebo group (10 cases),estrogen group (19 cases) and estrogen plus progesterone group (23 cases). Twenty healthy premenopausal women served as control group. The coagulation parameters were determined before and 3, 6 months after initiation of HRT. Results The levels of fibrinogen and protein S in postmenopausal women were significantly higher than those in the control group. There was no difference in coagulation parameters before and after placebo administration. After 3 month HRT, the fibrinogen levels in estrogen group and estrgoen plus progesterone group significantly decreased and further decreased after 6 month HRT, as compared with before HRT. A significant decrease was also noted in protein S in both groups after 3 month HRT, but returned closely to baseline after 6 month HRT. There was no significant difference in coagulation parameters between estrogen group and estrogen plus progesterone group either before or after HRT. Conclusion HRT significantly decrease the levels of fibrinogen in postmenopausal women.

关 键 词：雌激素替代治疗 血液凝固 绝经后期 

分 类 号：R588[医药卫生—内分泌]