分子参数对5-氟尿嘧啶-N-琥珀酰壳聚糖纳米粒理化性质的影响  

Effects of molecular parameter on physicochemical properties of 5-fluorouracil loaded N-Succinyl-Chitosan(Suc-Chi) nanoparticles

作　　者：颜承云[1] 谷继伟[1] 程岩[1] 于莲[1] 苏瑾[1] 孙维彤[1] 陈大为[2] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《黑龙江医药科学》2012年第1期28-29,共2页Heilongjiang Medicine and Pharmacy

基　　金：黑龙江省教育厅资助重点项目;编号:11531z09

摘　　要：目的:考察5-氟尿嘧啶-N-琥珀酰壳聚糖纳米粒(5-FU-Suc-Chi/NPs)理化性质影响因素。方法:采用乳化溶剂挥发法制备5-FU-Suc-Chi/NPs并考察其理化性质的影响因素。结果:5-FU-Suc-Chi/NPs的粒径、Zeta电位、包封率及载药量的大小与N-琥珀酰壳聚糖的取代度(DS)和分子量(Mw)有关。结论:N-琥珀酰壳聚糖的分子参数是影响5-FU-Suc-Chi/NPs理化性质的重要因素。Objective： To investigate the effects of molecular parameter on the physicochemical properties of 5-fluorouracil loaded N-Succinyl-chitosan nanoparticles（5-FU-Suc-Chi/NPs）.Methods：5-FU-Suc-Chi/NPs were prepared by an emulsification solvent diffusion method.Results：The physicochemical properties of 5-FU-Suc-Chi/NPs were related to the DS and Mw of Suc-Chi.Conclusion：The effects of the DS and Mw of Suc-Chi on the physicochemical properties of 5-FU-Suc-Chi/NPs are remarkable.

关 键 词：N-琥珀酰壳聚糖 纳米粒 理化性质 影响因素 

分 类 号：TQ46[化学工程—制药化工]