老年男性骨质疏松患者血清瘦素与骨密度及骨转换生化指标的关系  

Relationship between serum leptin,bone minaral density and bone biochemical turnover markers in aged males with osteoprosis

作　　者：柴瑛[1] 马利峰[1] 胡春荣[1] 邢冰[1] 

机构地区：[1]佳木斯大学附属第一医院,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2012年第1期30-31,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的：探讨老年男性骨质疏松患者血清瘦素（Leptin）水平的变化及其与骨密度（BMD）及骨转换生化指标的关系。方法：采用酶联免疫法（ELISA）测定89例老年男性骨质疏松患者和50例正常男性老年人血清Leptin、骨碱性磷酸酶（BAP）、骨钙素（BGP）、抗酒石酸酸性磷酸酶-5b（TRACP-5b）,采用美国NORLAND Excell-plus双能X线骨密度测定仪分别测定其正位腰椎（L2~4）及左侧股骨颈处BMD。结果：老年男性骨质疏松患者正位腰椎及左侧股骨颈BMD、血清Leptin、BAP、BGP水平较正常男性老年人明显降低（均P〈0.01）,血清TRACP-5b水平较正常男性老年人明显升高（P〈0.01）。老年男性骨质疏松患者血清leptin水平与患者正位腰椎及左侧股骨颈BMD、血清BAP、BGP水平呈明显正相关（r=0.437,r=0.496,r=0.512,r=0.489,均P〈0.01）,与患者血清TRACP-5b水平呈明显负相关（r=-0.529,P〈0.01）。结论：血清瘦素水平降低在老年男性骨质疏松的发病中可能发挥重要作用。Objective：To investigate the changes in serum leptin and the correlation between serum leptin and bone minaral dencity（BMD） and bone turnover biocamical markers.Methods：The serum leptin,bone alkaline phosphatase（BAP）,bone gla protein（BGP） and tartrate-resistant acid phosphate（TRACP-5b） were measured by using ELISA,the BMD of the lumber vertebrae 2～4（L2～4） and the neck of femur（Neck） were measured with dual energy X-ray absorptionetry in 89 aged males with osteoprosis and 50 normal aged males.Results：BMD of the lumber vertebrae 2-4 and the neck of femur,serum leptin,BAP and BGP were significantly lower（all P0.01）,serum TRACP-5b was significantly higher（P0.01） in the aged males with osteoprosis than those in normall aged males.A positive correlation was found between serum leptin and BMD of the lumber vertebrae 2-4 and the neck of femur and serum BAP and BGP（r=0.437,r=0.496,r=0.512,r=0.489,all P0.01）,a negative correlation was found between serum leptin and serum TRACP-5b（r=-0.529,P0.01）.Conclusion：The low serum concentration of leptin might play an important role in the development of osteoprosis in the aged male.

关 键 词：骨质疏松 瘦素 骨密度 骨转换生化指标 

分 类 号：R587.1[医药卫生—内分泌]