北京市社区人群血尿酸水平与肱-踝动脉脉搏波传导速度的关系  

Association between serum uric acid and brachial ankle pulse wave velocity in Beijing community residents

作　　者：马为[1] 杨颖[1] 齐丽彤[1] 赵锋[1] 张宝娓[1] 孟磊[1] 张岩[1] 蒋捷[1] 李建平[1] 朱赛楠[2] 王淑玉 霍勇[1] 

机构地区：[1]北京大学第一医院心内科,100034 [2]北京大学第一医院医学统计室,100034 [3]北京市高血压联盟

出　　处：《中华心血管病杂志》2012年第3期204-208,共5页Chinese Journal of Cardiology

基　　金：基金项目：“十一五”国家科技支撑计划（2006BAI01A02）

摘　　要：目的在北京市社区人群中探讨血尿酸水平与肱-踝动脉脉搏波传导速度（ba-PWV）的关系。方法2007至2008年，对北京市石景山2个社区的人群进行心血管危险因素的调查，并测量ba-PWV。选择其中2543名血尿酸和ba-PWV资料齐全者进行分析。ba—PWV≥1400cm／s定义为ba—PWV异常。分别根据男女性血尿酸水平的四分位数，将人群分为4组（Q1、Q2、Q3和Q4组）。以单因素logistic回归分析可能与ba-PWV异常有关联的心血管危险因素；以多因素logistic回归分析血尿酸水平与ba-PWV异常的关系。结果体质指数、甘油三酯、高血压患病率随血尿酸水平升高而增高（P均〈0．01）。单因素logistic回归分析显示年龄、性别、吸烟、高血压、收缩压、舒张压、糖尿病、体质指数、总胆固醇、甘油三酯和估算肾小球滤过率均与ba—PWV异常关联（P均〈0．01）；以Q1组为对照，Q4组ba-PWV异常的OR值为1．73（95％CI：1．34～2．22，P〈0．01）。调整年龄、性别、吸烟、高血压、收缩压、舒张压、糖尿病、体质指数、总胆固醇、甘油三酯和估算肾小球滤过率后，多因素logistic回归分析显示以Q1组为对照，Q4组ba—PWV异常的OR值为1．66（95％CI：1．16～2．37，P〈0．01），其中男性人群ba—PWV异常的OR值为1．55（95％C1：0．88—2．74，P〉0．05），女性人群ba—PWV异常的OR值为1．65（95％C1：1．04—2．64，P〈0．05）。结论在北京市社区人群中，血尿酸水平增高与ba—PWV异常独立相关。Objective To observe the relationship between serum uric acid and brachial ankle pulse wave velocity （ ba-PWV ） in Beijing community individuals. Methods This epidemiological survey was performed in residents of two communities from Shijingshan District in Beijing from 2007 to 2008. Cardiovascular risk factors and ba-PWV were measured. Two thousand five hundred and forty three individuals with both ba-PWV and serum uric acid measurements were included. Ba-PWV i〉 1400 cm/s was defined as abnormal. The individuals were divided into four groups （Q1, Q2, Q3 and Q4 group） according to the gender-specific quartiles of serum uric acid. Univariate logistic regression was used to evaluate the relation between various cardiovascular risk factors and ba-PWV abnormality. Multivariate logistic regression was used to evaluate the relation between serum uric acid and ba-PWV abnormality after adjusting for other cardiovascular risk factors. Results Body mass index, triglyeride and prevalence of hypertension increased with increasing levels of serum uric acid （ all P 〈 0. 01 ）. Univariate logistic regression analysis showed that age, gender, smoking, hypertension, systolic blood pressure, diastolic blood pressure, diabetes, body mass index, total cholesterol, triglyeride and estimated glomerular filtration rate were related with ba-PWV abnormality（ all P 〈 0. 01 ）. Compared with Q1 group, ba-PWV abnormality OR value of Q4 group was 1.73 （95% CI： 1.34 - 2. 22, P 〈 0.01 ）. Multivariate logistic regression revealed that ba-PWV abnormality OR value of Q4 group was 1.66 （95% CI： 1. 16 -2. 37, P〈0. 01 ） after adjusting for age, gender, smoking, hypertension, systolic blood pressure, diastolic blood pressure, diabetes, body mass index, total cholesterol, triglyeride and estimated glomerular filtration rate when compared with Q1 group and OR values were 1.55 （95% CI： 0.88 -2.74, P〉0.05） and 1.65 （95% CI： 1.04-2.64, P〈0.05） in male and female respectively. Conclusion Increased serum ur

关 键 词：尿酸 心血管疾病 社区医学 

分 类 号：R541.4[医药卫生—心血管疾病]