抗甲状腺药物致粒细胞缺乏症相关因素探讨  

Appraising the factors relevant to agranulocytosis induced by antithyroid drugs

作　　者：蒋晓真[1] 尹端六[2] 赵咏桔[2] 陈宇红[2] 罗邦尧[2] 

机构地区：[1]浦东新区人民医院,201200 [2]上海第二医科大学瑞金医院内分泌科

出　　处：《上海医学》2000年第5期276-278,共3页Shanghai Medical Journal

摘　　要：目的　探讨抗甲状腺药物 (ATD)引起粒细胞缺乏症的影响因素、治疗措施及周围血白细胞计数监测的重要性。方法　对 2 6例因抗甲状腺药物引起的粒细胞缺乏症住院患者进行回顾性分析。结果　ATD引起的粒细胞缺乏症不论服药剂量大小、患者年龄、服药时间长短、以及是否为初治或复治 ,均可发生。碳酸锂 ,G CSF、糖皮质激素对ATD引起的粒细胞缺乏症治疗效果明显。常规监测周围血白细胞发现的无感染症状粒细胞缺乏症恢复时间较有感染症状组快。结论　对服用ATD者均应常规监测周围血白细胞 ,以尽早发现粒细胞缺乏症患者。Objective To appraise the factors relevant to agranulocytosis induced by antithyroid drugs (ATD), the methods of treatment and the importance of monitoring. Method 26 patients with agranulocytosis induced by ATD were retrospectively analyzed. Results Agranulocytosis could occur in any patients inspite of the patients' age, dose, duration of ATD treatment whether primary or secondary. Lithium carbonate, G CSF and glucocorticoids were very effective in agranulocytosis induced by ATD. The recovery time was shorter in agranulocytosis without infection than that with infection. Conclusion Any patients with ATD should monitor the white cell count for early detection of agranulocytosis.(Shanghai Med J, 2000,23∶276 278)

关 键 词：抗甲状腺药物 粒细胞缺乏症 药物不良反应 ATD 

分 类 号：R595.3[医药卫生—内科学]