苍耳化学成分的分离与鉴定  

Isolation and identification of chemical constituents in Xanthium sibiricum

作　　者：胡冬燕[1] 杨顺义[1] 袁呈山[2] 韩广田[2] 沈慧敏[1] 

机构地区：[1]甘肃农业大学草业学院,甘肃兰州730070 [2]兰州大学功能有机分子化学国家重点实验室,甘肃兰州730000

出　　处：《中草药》2012年第4期640-644,共5页Chinese Traditional and Herbal Drugs

基　　金：甘肃省农业生物技术研究与应用开发项目(GNSW-2004-08);甘肃省教育厅基金项目(032-06)

摘　　要：目的对苍耳Xanthium sibiricum地上部分的化学成分进行分离和鉴定。方法采用硅胶柱色谱、制备薄层色谱、MCI凝胶色谱和Sephadex LH-20柱色谱等方法对其化学成分进行分离纯化,应用现代波谱技术ESI-MS、1H-NMR、13C-NMR对化合物的结构进行鉴定。结果从苍耳中分离得到了7个倍半萜类化合物,分别为苍耳农(1)、苍耳亭(2)、3-cycloheptene-1-acetic acid(3)、xanthinosin(4)、inusoniolide(5)、5-azuleneacetic acid(6)、2-hydroxy xanthinosin(7)。结论化合物1为新化合物,命名为苍耳农,化合物3、6、7为首次从苍耳植物中分离得到,化合物5为首次从苍耳属植物中分离得到,其中化合物2的量较丰富(0.1%),为开发新型植物源杀菌剂奠定了基础。Objective To study the chemical constituents in the aerial part of Xanthium sibiricum.Methods Compounds were isolated by repeated silica gel,preparative TLC,MCI,and Sephadex LH-20 column chromatography.Their structures were identified by their spectroscopic data.Results Seven compounds of susquiterpene were isolated and identified as xanthnon（1）,xanthatin（2）,3-cycloheptene-1-acetic acid（3）,xanthinosin（4）,inusoniolide（5）,5-azuleneacetic acid（6）,and 2-hydroxy xanthinosin（7）,respectively.Conclusion Compound 1 is a new compound named xanthnon,componds 3,6,and 7 are obtained from this plant for the first time,and compound 5 is yielded from the plants in Xanthium L.for the first time.Among them,compound 1 accounts for 0.1% of the acrial part of X.sibiricum and has the potential to be exploited as a novel bactericide.

关 键 词：苍耳 倍半萜 苍耳农 苍耳亭 inusoniolide 

分 类 号：R284.1[医药卫生—中药学]