含苯并噻唑基肉桂双酰胺的合成及其生物活性  

Synthesis and Biological Activity of Novel Benzethiozolyl Cinnamon Bisamides

作　　者：何勇[1] 杨涛[1] 祁慧雪[1] 薛伟[1] 

机构地区：[1]贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室,贵州贵阳550025

出　　处：《广州化工》2012年第6期56-59,共4页GuangZhou Chemical Industry

基　　金：贵州大学引进人才科研基金(No.201122)

摘　　要：以肉桂酸和取代邻氨基苯甲酸为起始原料,合成了9个含苯并噻唑基肉桂双酰胺化合物,其结构经1HNMR、13CNMR、IR和元素分析确证。MTT法进行抑制PC3癌细胞体外活性测试,结果表明所合成的化合物对PC3细胞有一定抑制活性,其中化合物E8在1μmol.L-1浓度下对PC3的抑制率为71.4%。Nine novel bisamides compounds containing cinnamon and benzothiazole were synthesized with cinnamic acid and amino acid instead of adjacent as the starting material.Their structures were characterized by 1H NMR,13C NMR,IR and elemental analysis.Preliminary bioassay indicated that some compounds posed antitumor activity to PC3 cells in vitro by MTT method.The antiproliferation activity of compound E8 to PC3 cells at the concentration of 1 μmol·L-1 was 71.4%.

关 键 词：苯并噻唑 肉桂双酰胺 合成 生物活性 

分 类 号：O626[理学—有机化学]