阳离子交换树脂分离纯化石杉碱甲的工艺研究  

Study on separation and purification of Huperzine A by cation exchange resin

作　　者：李俊[1] 姚茂君[1,2] 朱士龙[1] 杨岳平[1] 

机构地区：[1]吉首大学化学化工学院,湖南吉首416000 [2]湖南省林产化工重点实验室,湖南张家界427000

出　　处：《应用化工》2012年第3期424-426,共3页Applied Chemical Industry

基　　金：国家发改委国家生物医药高技术产业化项目(发改委高技[2007]2490号)

摘　　要：研究了5种离子交换树脂对石杉碱甲的吸附量和解吸率。结果表明,C004阳离子交换树脂的效果最好,其最佳工艺参数为:上柱液pH=3.0,上柱流速为3 BV/h,洗脱剂用3 mol/L氨水-70%乙醇,洗脱剂体积3 BV,洗脱速率1 BV/h。在此优化条件下,产品中的石杉碱甲含量可达5%。The adsorption capacities and the desorptions of five different ion exchange resins towards Huperzine A were studied.The results showed that C004 cation exchange resin exhibited the best effects.The optimal technological parameters were as follows：the pH value of sample solution 3.0,flow rate 3 BV/h,3 mol/L ammonia water-70% ethanol of elution,elution volume 3 BV,elution velocity 1 BV/h.Under the optimum conditions,the content of Huperzine A was up to 5%.

关 键 词：石杉碱甲 蛇足石杉 阳离子交换树脂 洗脱 

分 类 号：TQ028.3[化学工程]