Cbz保护的氮杂环庚酮合成  

Synthesis of aza-cycloheptanone protected by Cbz

作　　者：王宝龙[1] 兰婷[1] 路丽华[1] 李明华[1] 何炜[1] 

机构地区：[1]第四军医大学药学院化学教研室,陕西西安710032

出　　处：《应用化工》2012年第3期546-547,共2页Applied Chemical Industry

摘　　要：以4-哌啶酮盐酸盐为原料,经过Cbz保护、卡宾插入、脱除酯基,合成氮杂环庚酮,总收率87%,其结构经过1H NMR和MS表征。Aza-cycloheptanone was synthesized from 4-piperidone monohydrate hydrochloride by three-steps reaction of protection,Schimit reaction and deesterification.The total yield was 88%,the structure was characterized by 1H NMR and MS.

关 键 词：氮杂环庚酮 卡宾 合成 

分 类 号：TQ216[化学工程—有机化工] O622.5[理学—有机化学]