结核病院住院肺结核病人菌株分布及耐药结果分析  

The analysis of the Strain distribution of hospitalized tuberculosis patients and drug resistance results

作　　者：陶波山 

机构地区：[1]北海市结核病防治院,广西北海536000

出　　处：《临床肺科杂志》2012年第5期855-856,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨结核病院住院肺结核病人的病原菌分布特点及耐药情况。方法对住院肺结核病人498份痰标本做各种病原菌培养。结果共培养出644份菌株。结核分枝杆菌190株,4种一线抗结核药的耐药率是链霉素26.5%、异烟肼24.9%、利福平22.7%、乙胺丁醇10.3%。革兰阴性杆菌318株,耐药率最高的依次是氨苄西林、头孢唑啉。革兰阳性球菌34株,耐药率最高的依次是青霉素、氨苄西林、庆大霉素。真菌98株,耐药率最高的依次是益康唑和氟康唑。结论住院肺结核病人检出菌株以革兰阴性杆菌最多,真菌检出率也较高,结核杆菌、革兰阴性杆菌和革兰阳性球菌对多种药物有很高的耐药率。Objective To evaluate the distribution characteristics of pathogens and drug resistance in hospitalized tuberculosis patients.Methods On hospital tuberculosis patients＇ 498 sputum samples do all kinds of pathogenic bacteria development.Results Out of 644 strains of training.Mycobacterium tuberculosis of 190 plants,Four kinds of first-line anti-TB drug resistance rates are Streptomycin 26.5%,Isoniazid 24.9%,Rifampicin 22.7%,Ethambutol 10.3%.Gram-negative bacillus 318 strains,Resistance are the highest rates of ampicillin,cefazolin.Gram-positive bacteria 34 strains,Resistance are the highest rates of penicillin,ampicillin,gentamicin.Fungi 98 strains,Resistance are the highest rate of econazole and fluconazole.Conclusion Hospital tuberculosis patients detected by gram-negative bacteria strains most.Fungi detection rate is higher also.The mycobacterium tuberculosis,gram-negative bacilli and Gram-positive bacteria have very high resistance to many kinds of drug.

关 键 词：肺 结核 细菌 抗药性 

分 类 号：R446.5[医药卫生—诊断学]