胸水中脂阿拉伯甘露聚糖抗原检测对结核性胸膜炎的诊断价值  

Diagnostic significance of lipoarabinomannan antigen in pleural fluid for tuberculous pleurisy

作　　者：王芳[1] 乐军[1] 彭荣[1] 

机构地区：[1]同济大学附属上海市肺科医院检验科,上海200433

出　　处：《检验医学》2012年第3期199-201,共3页Laboratory Medicine

摘　　要：目的探讨胸水中的脂阿拉伯甘露聚糖(LAM)抗原对结核性胸膜炎的诊断价值,以获取一种诊断结核性胸膜炎的辅助指标。方法收集胸水标本共96例,其中结核性胸膜炎46例,非结核性胸膜炎50例,采用双抗体夹心酶联免疫吸附试验(ELISA)检测胸水中的LAM抗原。结果结核性胸膜炎胸水中LAM抗原阳性率为54%,非结核性胸膜炎胸水中LAM抗原阳性率为22%,二者差异有统计学意义(P<0.05)。结论胸水中LAM抗原检测可作为结核性胸膜炎诊断的一项新指标。Objective To investigate whether the determination of lipoarabinomannan（LAM） antigen in pleural fluid may be used as an indicator for the diagnosis of tuberculous pleurisy.Methods Double antibody sandwich enzyme-linked immunosorbent assay（ELISA） was performed to detect LAM antigen in 96 pleural fluid samples（46 patients with tuberculous pleurisy and 50 patients with non-tuberculous pleurisy）.Results The positive rate of LAM antigen in pleural fluid with tuberculous pleurisy group was 54%,and the positive rate in pleural fluid with non-tuberculous pleurisy was 22%.There was a statistical difference between them（P0.05）.Conclusions LAM antigen could be used as a new indicator for the diagnosis of tuberculous pleurisy.

关 键 词：脂阿拉伯甘露聚糖 胸水 结核性胸膜炎 

分 类 号：R521.7[医药卫生—内科学]