可溶性髓样细胞触发受体-1对严重多发伤患者继发感染早期诊断价值探讨  

Clinical value of soluble triggering receptors expressed on myeloid cells-1 for the early diagnosis of infection in patients with severe multiple injury

作　　者：徐志康[1] 刘和录[1] 陈望[1] 刘镇平[1] 赖剑波[2] 华建江[1] 朱惠君[1] 

机构地区：[1]广州医学院附属深圳沙井医院检验科,518104 [2]广州医学院附属深圳沙井医院中心ICU,518104

出　　处：《国际检验医学杂志》2012年第5期528-529,共2页International Journal of Laboratory Medicine

基　　金：深圳市科技计划资助项目(201002150)

摘　　要：目的探讨可溶性髓样细胞触发受体-1(sTREM-1)对严重多发伤患者继发感染的早期诊断价值。方法测定57例损伤严重度评分不低于16分的多发伤患者血清sTREM-1、降钙素原(PCT)和C反应蛋白(CRP)含量,并与健康对照组进行比较,应用ROC曲线进行分析。结果与健康对照组比较,多发伤未继发感染和继发感染患者血清sTREM-1、PCT和CRP水平升高(P<0.05);继发感染组血清sTREM-1和PCT水平高于非感染组(P<0.05),CRP水平比较差异无统计学意义(P>0.05)。sTREM-1、PCT和CRP的ROC曲线下面积分别为0.954,0.863和0.785;最佳阈值分别为8.79、8.16ng/mL和69.47mg/L,灵敏度分别为0.912、0.787和0.938,特异度分别为0.894、0.845和0.513。结论血清sTREM-1是早期诊断严重多发伤患者继发感染的较好指标,其诊断效能优于PCT和CRP。Objective To investigate the clinical value of soluble triggering receptors expressed on myeloid cells-1（sTREM-1） for the early diagnosis of infection in patients with severe multiple injury.Methods Serum sTREM-1,PCT and CRP level in 57 patients with severe multiple injury with ISS≥16 and healthy controls were detected and ROC analysis was performed.Results Compared with the control group,serum sTREM-1,PCT and CRP level in multiple injury with secondary infection and without secondary infection groups were increased（P0.05）.Compared with patients without infection,serum sTREM-1 and PCT levels in patients with infection were increased（P0.05）,but there was no significant difference of serum CRP level（P0.05）.The area under ROC curve of sTREM-1,PCT and CRP were 0.954,0.863 and 0.785,with best threshold of 8.79,8.16 ng/mL and 69.47 mg/L,sensitivity of 0.912,0.787,0.938 and specificity of 0.894,0.845 and 0.513.Conclusion Serum sTREM-1 could be a fine early diagnostic marker of infection in patients with severe multiple injury,with better diagnostic performance than PCT and CRP.

关 键 词：可溶性髓样细胞触发受体-1 降钙素原 C反应蛋白 多发伤 

分 类 号：R641[医药卫生—外科学]