呼吸科重症监护病区患者下呼吸道标本多药耐药鲍曼不动杆菌耐药性及同源性分析  

Drug resistance and homology analysis of multi-drug resistant Acinetobacter baumanni in lower respiratory tract specimens from patients in intensive care unit of respiration department

作　　者：王璐[1] 万楠[1] 孟冬娅[1] 

机构地区：[1]沈阳军区总医院检验科,辽宁沈阳110840

出　　处：《国际检验医学杂志》2012年第6期679-680,共2页International Journal of Laboratory Medicine

摘　　要：目的分析多药耐药鲍曼不动杆菌(MDR-Aba)的耐药性和同源性。方法 2007年10月至2008年12月该院呼吸科ICU患者下呼吸道标本MDR-Aba12株,K-B纸片扩散法检测菌株对等14种抗菌药物的敏感性,脉冲场凝胶电泳(PFGE)分析菌株同源性。结果 12株MDR-Aba对头孢菌素类、碳青霉烯类、氨基糖苷类、氟喹喏酮类等抗菌药物耐药性较高;PFGE分型显示11株来源于相同克隆株,另外1株为不同亚型。结论 2007年10月至2008年12月该院呼吸科ICU存在相同克隆株MDR-Aba的流行。Objective To investigate the drug resistance and homology of multi-drug resistant Acinetobacter baumannii（MDR-Aba）.Methods 12 strains of MDR-Aba,isolated from lower respiratory specimens of patients in intensive care unit of Respiratory Department in this hospital during Oct.2007 and Dec.2008,were analyzed for resistance to 14 antibacterials by K-B method and for homology by pulsed-field gel electrophoresis（PFGE）.Results Total 12 trains of MDR-Aba were highly resistant to cephalosporins,carbopenems,aminoglycosides and fluoroquinolones.According to PFGE typing,11 in the 12 strains were from the same clone and 1 was of different sub-clone.Conclusion There might be prevalence of MDR-Aba from the same clone in this hospital during Oct.2007 and Oct.2007 and Dce.2007.

关 键 词：鲍氏不动杆菌 多重耐药性 同源性 

分 类 号：R446.5[医药卫生—诊断学]