2011年夏季某院分离志贺菌特点及某地区志贺菌血清型流行趋势分析  

Characters of shigella strains in certain hospital and epidemic tendency analysis of shigella serotypes in ceratin area

作　　者：刘志远[1,2] 马玉芝[1] 潘健[1] 张婷菊[1] 康利新[1] 刘贵建[1] 

机构地区：[1]中国中医科学院广安门医院检验科,100053 [2]北京大学医学部基础医学院病原生物学系,100191

出　　处：《国际检验医学杂志》2012年第6期715-716,718,共3页International Journal of Laboratory Medicine

摘　　要：目的了解该院2011年分离的志贺菌及相关病例特点,结合其他区县志贺菌分离情况,总结北京市志贺菌血清型转变特点。方法 VitekⅡCompact鉴定志贺菌,血清玻片凝集法鉴定血清型,药敏试验采用K-B法。结果共分离获得志贺菌15株,其中宋内Ⅰ型14株,福氏F2a型1株;15株菌对复方新诺明、哌拉西林、氨苄西林均耐药,14株宋内Ⅰ型菌对环丙沙星、左氧氟沙星、阿米卡星、头孢他啶、头孢西丁、亚胺培南、头孢吡肟、氨曲南、哌拉西林/他唑巴坦均敏感。结论宋内Ⅰ型志贺菌为主要分离菌,对环丙沙星、左氧氟沙星、阿米卡星、头孢他啶、头孢西丁、亚胺培南、头孢吡肟、氨曲南、哌拉西林/他唑巴坦保持高度敏感;宋内志贺菌已成为北京市流行志贺菌的主要血清型。Objective To analyze the epidemiological features of shigella strains separated in this Hospital in 2011,and to the explore variation trend of shigella serotypes in Beijing.Methods Shigella strains were identified with Vitek Ⅱ Compact.Serotype was detected with serological testing.Drug susceptibility was determined by K-B methods.Results 15 strains of shigella were isolated,including 14 of Shigella sonnei and 1 of Shigella flexneri.No strains were sensitive to Trimethoprim-sulfamethoxazole,Piperacillin,Ampicillin.All Shigella sonnei strains were sensitive to Ciprofloxacin,Levofloxacin,Amikacin,Cefoxitin,Ceftazidime,Aztreonam,Cefepime,Imipenem,Piperacillin-tazobactam.Conclusion Shigella sonnei might be new prevalent serotype in Beijing.It might be improper to perform drug susceptibility only for ampicillin,a fluoroquinolone,and trimethoprim-sulfamethoxazole as suggested by CLSI.

关 键 词：志贺菌 宋氏 血清学分型 药敏试验 流行 

分 类 号：R446.5[医药卫生—诊断学]