MicroRNA与心血管疾病  

MicroRNA and Cardiovascular Diseases

作　　者：毛安琼[1] 姚怡[1] 段晓霞[1] 王晓斌[1] 

机构地区：[1]泸州医学院附属医院麻醉科,四川泸州646000

出　　处：《医学综述》2012年第6期801-804,共4页Medical Recapitulate

基　　金：四川省科技厅国际合作课题(2011HH0031)

摘　　要：MicroRNA(miRNA)是一类具有转录后调节活性的内源性小分子RNA,通过碱基互补配对,与靶信使RNA(mRNA)的3'端非编码区(3'-UTR)序列相互识别,引起靶mRNA的降解和(或)翻译抑制。最近研究表明,miRNAs在血管和心脏中高度表达,而在病变的血管中,心肌缺血和缺血性心律失常中它们的表达是失调的,miRNAs可作为心血管疾病的新型治疗靶标。现回顾总结有关miRNAs在心血管疾病中作用的研究进展。MicroRNA（miRNA）are a class of endogenous small RNA involved in post-transcriptional regulation through binding to complementary sequences that are usually located in the 3′-untranslated region（3′-UTR）of target mRNA,then trigger mRNA cleavage and/or translational repression.Recent studies have identified that miRNAs are highly expressed in vasculature and heart and their expression is dysregulated in diseased vessels,myocardial ischemia and ischemic arrhythmia.miRNAs may serve as novel therapeutic targets for cardiovascular diseases.Here is to make a review on the research progress regarding the roles of miRNAs in cardiovascular diseases.

关 键 词：MICRORNA 心血管疾病 心肌缺血 缺血性心律失常 

分 类 号：R54[医药卫生—心血管疾病]