人类白细胞抗原与血管病变的相关研究  

Research on Correlation between Human Leukocyte Antigen and Vascular Lesions

作　　者：徐海凤[1,2] 沈捷[1,2] 马向华[1,3] 

机构地区：[1]南京医科大学第一附属医院 [2]江苏省人民医院HLA实验室,南京210029 [3]江苏省人民医院内分泌科,南京210029

出　　处：《医学综述》2012年第6期813-815,共3页Medical Recapitulate

摘　　要：人类白细胞抗原(HLA)基因群包括100多个基因座位,共554个等位基因,位于6号染色体的短臂上,全长3600 kb,是调控人体特异性免疫应答和决定疾病易感性个体差异的主要基因系统。与HLA相关的血管病变主要有动脉炎、动脉粥样硬化、糖尿病血管并发症、老年性黄斑变性等。近几年的研究表明,它们的发病机制均与非特异性炎症和氧化应激有一定关系。现对上述几种疾病与HLA基因型特性相关的研究进展予以综述。Human leukocyte antigen（HLA）genes are locate in the short arm of the chromosome 6.Its full length is about 3600 kb,and it comprises 554 alleles.It belongs to the gene system that regulates human-specific immune response and determines individual differences of major disease susceptibility.Vascular lesions associated with HLA mainly contain arterial vascular inflammation,atherosclerosis,diabetic vascular complications and age-related macular degeneration.In recent years,studies have shown that the pathogenesis of the above mentioned diseases have a certain relationship with nonspecific inflammation and oxidate stress.Here is to make a review on the study progress of relationship between the above mentioned diseases and HLA genotypic characteristics.

关 键 词：人类白细胞抗原 动脉炎 动脉粥样硬化 糖尿病血管并发症 白塞病 

分 类 号：R318[医药卫生—生物医学工程]