CXCL12/CXCR4生物学轴与膀胱肿瘤关系的研究进展  

Research Progress on CXCL12/CXCR4 Axis in Bladder Tumor

作　　者：王振[1,2] 杨德林 辛明明[1,2] 杨德林 

机构地区：[1]昆明医学院第二附属医院泌尿外科 [2]云南省泌尿外科研究所,昆明650101

出　　处：《医学综述》2012年第6期843-846,共4页Medical Recapitulate

基　　金：云南科技厅昆明医学院联合专项基金(2007C0016R);云南省应用基础研究基金(2008ZC135M)

摘　　要：趋化因子是促炎症趋化细胞因子类家族成员之一,它在许多生理和病理过程中有重要作用。研究发现趋化因子CXCL12和受体CXCR4广泛表达于组织和器官,与膀胱肿瘤细胞的黏附、侵袭、增殖和生存有关。通过阐明CXCL12/CXCR4生物学轴和膀胱肿瘤的关系,以便寻找有利于疾病治疗的新途径。Chemokine is a member of the large family of pro-inflammatory chemotactic cytokines,which plays a very important role in many physiological and pathological processes.CXCL12 and its receptor CXCR4 were demonstrated to be widely expressed in a broad array of tissues and organs.Related studies suggested that CXCL12/CXCR4 axis was related to the adhesion,invasion,proliferation and survival of bladder tumor cells.Elucidating the relationship between the CXCL12/CXCR4 axis and bladder tumor is helpful to find a new way to treat the disease.

关 键 词：CXCL12 CXCR4 膀胱肿瘤 

分 类 号：R286.91[医药卫生—中药学]