系统性红斑狼疮患者贫血发生机制的研究  

The Pathogenesis of Anemia in Patients with Systemic Lupus Erythematosus

作　　者：赵永琴[1] 林珺芳[1] 陈君敏[1] 

机构地区：[1]福建医科大学附属第一医院血液风湿内科,福州350005

出　　处：《医学综述》2012年第6期876-879,共4页Medical Recapitulate

基　　金：2008年福建省卫生厅青年科研课题(2008-2-27)

摘　　要：系统性红斑狼疮(SLE)的病因复杂,尚不明确,其发病机制与免疫机制紊乱及免疫复合物形成有关。SLE患者在血液系统中的损害以贫血最常见,部分患者早期可以贫血为首发表现。SLE患者贫血的发病机制亦十分复杂,它不仅与自身致病性抗体的产生,T、B细胞过度增殖与活化,细胞因子分泌及受体表达等免疫因素有关,还与感染、恶性肿瘤、慢性肾脏病、药物、慢性失血、营养元素吸收障碍等非免疫因素有关。The pathogeny of systemic lupus erythematosus（SLE）is complex,not clear,and its pathogenesis is related to disorder of immune mechanism and the formation of immune complex.The anemia of hematological impairment is most common manifestation in systemic lupus erythematosus patients and some patients with anemia as the first symptom.The pathogenesis of anemia is very complex too.It is related to not only its pathogenic antibody of oneself,T,B lymphocyte excessive proliferation and activation,cytokine secretion and receptor expression abnormity and other immune factor,but also infection,malignant tumor,chronic kidney disease,medications,chronic blood loss,malabsorption of nutrient elements and other nonimmune factors.

关 键 词：系统性红斑狼疮 贫血 免疫因素 非免疫因素 

分 类 号：R593.241[医药卫生—内科学]