蛇毒降纤酶治疗脑卒中后脑水肿的机制研究新进展  

Progress on the New Mechanism of Venom Defibrase in Brain Edema after Stroke

作　　者：卜宪聪[1] 刘诗翔[1] 

机构地区：[1]成都军区昆明总医院神经内科,昆明650032

出　　处：《医学综述》2012年第6期882-886,共5页Medical Recapitulate

摘　　要：脑卒中在我国是一种严重的疾病。脑水肿在脑出血后的继发性脑损伤中起着重要的作用,是严重的并发症,其机制不清。蛇毒降纤酶可有效抑制血栓的形成且溶解血栓,目前已被广泛用于急性缺血性脑卒中的治疗。动物研究表明,蛇毒素能清除氧自由基、下调c-fos基因的表达,以及减少补体浸润等作用,能减轻脑缺血后脑水肿和脑损伤。现将蛇毒降纤酶对脑卒中后脑水肿的机制研究现状予以综述。Stroke is a serious disease in China.Brain edema plays an important role in intracerebral hemorrhage secondary brain injury,which is a serious complication,whereas the mechanism is unclear.Snake venom defibrase can effectively inhibit thrombus formation and dissolution of blood clots,which has been widely used in the treatment of acute ischemic stroke.Animal studies have shown that snake toxins can remove oxygen free radicals,reduced the expression of c-fos gene,reduce the role of complement infiltration,ischemic brain edema and brain damage.The mechanisms of venom defibrase function on brain edema after stroke is to be reviewed here.

关 键 词：蛇毒降纤酶 脑卒中 脑水肿 

分 类 号：R743.3[医药卫生—神经病学与精神病学]