比例辅助通气与持续正压通气在幼兔胎粪吸入模型上的应用比较  

Comparison of Proportional Assist Ventilation and Continuous Positive Airway Pressure in young rabbits with meconium aspiration

作　　者：武荣[1] 李娜[1] 周海燕[1] 刘石[1] 

机构地区：[1]安徽医科大学淮安市妇幼保健院新生儿科,223002

出　　处：《重庆医学》2012年第10期968-969,共2页Chongqing medicine

基　　金：淮安市S科技支撑计划基金资助项目(HAS2010035)

摘　　要：目的比较比例辅助通气(PAV)与持续正压通气(CPAP)在幼兔胎粪吸入模型应用的相关指标。方法将24只幼兔随机分为PAV组、CPAP组和氧疗组,每组各8只。三组幼兔均予气管插管后注入4mL/kg的45mg/mL胎粪混合物,PAV组和CPAP组在胎粪灌入后10min实施通气;氧疗组给予头罩吸氧治疗,初调吸入氧浓度(FiO2)为0.5,观察治疗3h后兔的呼吸频率(RR)、心率(HR)、血气等指标的变化。结果三组间胎粪吸入新生兔的RR、HR、血气分析的数值比较差异有统计学意义;PAV组与CPAP和氧疗组比较差异有统计学意义(P<0.05);CPAP组和氧疗组比较差异无统计学意义(P>0.05)。结论 PAV对幼兔胎粪吸入综合征(MAS)模型的治疗效果优于CPAP。Objective To compare the relevant indicators in the proportional assist ventilation（PAV） and continuous positive airway pressure（CPAP） in young rabbits with meconium aspiration.Methods Twenty four newborn rabbits were divided randomly and medially into PAV group,CPAP group,and oxygen inhalation therapy group.4 mL/kg meconium solutions were injected into the endotracheal tube in all rabbits of three groups.The rabbits of PAV group and CPAP group were treated by PAV and CPAP 10 minutes after meconium aspiration.The rabbits of oxygen inhalation therapy group were treated by oxygen hood（FiO2：0.5）.The respiratory rate（RR）,heart rate（HR）,and blood gas analysis were observed at 3 hour after treated.Results There are statistically significant differences in RR,HR,and blood gas analysis values among the three groups,and also between PAV group and oxygen inhalation therapy group（P0.05） or PAV group and CPAP group（P0.05）.There were no statistically significant differences in RR,HR,and blood gas analysis values between CPAP group and oxygen therapy group（P0.05）.Conclusion The PAV mode is better than CPAP mode in treating young rabbits with meconium aspiration.

关 键 词：比例辅助通气 胎粪吸入综合征 幼兔 

分 类 号：R722.1[医药卫生—儿科]