四川遂宁地区居民乙肝病毒基因型别分析  

HBV Genotype Research Among Residents in Suining,Sichuan

作　　者：姚成[1] 张爽[2] 沈丽萍[2] 刘宗林[1] 刘文武[1] 毕胜利[2] 

机构地区：[1]遂宁市疾病预防控制中心,四川遂宁629000 [2]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《预防医学情报杂志》2012年第3期213-215,共3页Journal of Preventive Medicine Information

摘　　要：目的了解遂宁地区人群乙型肝炎病毒(HBV)基因型及血清亚型流行特征。方法在遂宁6个县级行政区域内共采集血清样本1 468人份筛出HBsAg检测阳性的血清样本,用巢氏PCR法扩增提取HBV DNA S区,根据PCR产物基因测序结果对样本HBV进行基因分型。结果测出基因序列118例HBsAg阳性标本中,B基因型40例(33.89%),C基因型73例(61.86%),D基因型5例(4.23%),未发现BCD以外的其他基因型。42份(35.59%)血清亚型分型为adr型,76份(64.41%)为adw型。结论遂宁地区乙肝病毒基因型别以B、C为主要基因型,其中C型基因占优势,存在少量D基因型。血清亚型的分布以adr\adw亚型为主,其中adw亚型占优势。Objective To understand the epidemiological characteristics of HBV genotypes and serotypes among population in Suining.Method Totally 1 468 serum samples were collected from residents in 6 counties of Suining to screen HBsAg positive samples,followed by amplification of S region by nest-PCR and HBV genotype determination by DNA sequencing methods.Results.Genotyping 118 HBsAg positive samples,40 of the samples showed genotype B（33.89%）,73 samples of genotype C（61.86%）,5 samples of genotype D（4.23%）.Other genotypes were not found.There were 42 samples of serotype adr（35.59%） and 76 samples of serotype adw（64.41%）.Conclusion HBV genotypes were mainly B and C subtypes in Suining area and genotype C was dominant,while few HBV of genotype D was identified.Serotype distribution was mainly adr/adw,in which subtype adw was the dominant serotype.

关 键 词：乙型肝炎病毒 基因型 血清亚型 分布 

分 类 号：R512.62[医药卫生—内科学]