自拟活血通脉灵对心肌缺血大鼠SOD活性和MDA含量的影响  

Effects of Huoxuetongmailing on SOD activity and MDA content in myocardial ischemic rats

作　　者：李宏林 王炜 杜英[3] 

机构地区：[1]河北冀中能源邯郸矿业集团机关门诊部,056002 [2]河北省邯郸市商业职工医院全科,056001 [3]河北工程大学医学院中医基础教研室,056029

出　　处：《疑难病杂志》2012年第4期277-279,共3页Chinese Journal of Difficult and Complicated Cases

基　　金：邯郸市科学技术研究与发展计划资助项目(No.0828108063-3)

摘　　要：目的探讨活血通脉灵(HXTML)对异丙肾上腺素(ISO)所致心肌缺血大鼠心肌超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量的影响。方法将50只Wistar雄性大鼠随机分为空白对照组、模型组、阿司匹林组及活血通脉灵大剂量治疗组(HXTMLmax)和小剂量治疗组(HXTMLmin),采用ISO复制心肌缺血模型,观察心肌组织中SOD活性和MDA含量的变化。结果与空白对照组比较,模型组SOD活性明显下降,MDA含量增加(P<0.01);与模型组比较,阿司匹林组、HXTMLmax组和HXTMLmin组SOD活性增高、MDA含量降低(P<0.05或P<0.01);与阿司匹林组比较,HXTMLmax组和HXTMLmin组SOD活性升高、MDA含量下降(P<0.05,P<0.01);而HXTMLmax组与HXTMLmin组比较,差异无统计学意义(P>0.05)。结论活血通脉灵能提高心肌缺血损伤大鼠心肌组织中SOD活性,降低MDA含量,具有一定抗心肌氧化损伤作用。Objective To study the effects of Huoxuetongmailing on superoxide dismutase（SOD） activity and malondiadehyde （MDA） content in myocardial ischemic rats induced by isoproterenol（ISO）.Methods Fifty healthy male Wistar rats were randomly divided into five groups,namely with control group,model group,aspirin treatment group,max dose of Huoxuetongmailing（HXTMLmax） treatment group and min dose of Huoxuetongmailing（HXTMLmin） treatment group.The activity of SOD and the content of MDA in myocardial tissue were measured.Results Compared with the control group,the activity of SOD was lower and the content of MDA was higher in model group（P 0.01）.The activity of SOD in aspirin,HXTMLmax and HXTMLmin treatment group were higher than those in model group,and the content of MDA were lower（P 0.05 or P 0.01）.There was no statistical difference between HXTMLmax and HXTMLmin treatment group （P 0.05）.Conclusion The Huoxuetongmailing could increase the SOD activity and decrease the MDA content in myocardial ischemic rats,which is indicated that it could resist oxidative damage of myocardial ischemia and protect heart tissue.

关 键 词：活血通脉灵 心肌缺血 异丙肾上腺素 超氧化物歧化酶 丙二醛 大鼠 

分 类 号：R285.5[医药卫生—中药学]