经颅多普勒对高脂血症患者脑血流动力学的分析  

Cerebral hemodynamic changes in hyperlipemia patients with transcranial Doppler

作　　者：李艳[1] 傅津津[1] 李科[1] 田发发[1] 秦群[1] 宋明谕[1] 

机构地区：[1]中南大学湘雅医院健康管理中心,长沙410008

出　　处：《中南大学学报（医学版）》2012年第3期256-259,共4页Journal of Central South University ：Medical Science

摘　　要：目的:分析高脂血症患者脑血流动力学的改变,探讨经颅多普勒(transcranial Doppler,TCD)对高脂血症患者的临床应用价值。方法:应用TCD检测63例高脂血症患者(高脂血症组)脑血流动力学的改变,并与64例血脂正常者(对照组)进行比较分析。结果:两组间相同脑动脉的血流速度及搏动指数(pulsatile index,PI)差异无统计学意义(P>0.05)。高脂血症组频谱形态异常者有52例,占82.54%,与对照组比较差异有统计学意义(P<0.005),其中仅有椎基底动脉系统频谱形态异常者22例,仅有颈内动脉系统频谱形态异常者2例,两者均有频谱形态异常者28例,椎基底动脉系统频谱形态异常率明显高于颈内动脉系统(P<0.005)。结论:经颅多普勒检查显示高脂血症患者常合并脑动脉频谱形态异常,并以椎基底动脉系统为主,提示TCD对高血脂患者脑动脉变化有一定的临床价值。Objective： To analyze cerebral hemodynamic changes by means of transcranial Doppler （TCD） and generally to explore the clinical application of this method in hyperlipemia patients. Methods： Cerebral hemodynamics were detected by TCD in 63 patients with hyperlipidemia and compared with the hemodynamics of 64 health people. Results： No statistically significant changes were found in the cerebral artery blood flow velocity and pulsatility index between the hyperlipidemic and control groups （P〉0.05）. Spectral shape, however, was abnormal in 52 patients in the hyperlipemia group （82.54%）, which was statistically different （P〈0.005） from controls. These abnormalities were classed as follows： 22 patients had abnormal spectra of the vertebrobasilar system, 2 patients had abnormal spectrum of the internal carotid arterial system, and 28 patients had abnormal spectra of both systems. The incidence of the abnormal spectra in vertebrobasilar system was significantly higher than the internal carotidartery （v^0.00s）. Conclusion： TCD examination can reveal abnormal spectral shape in the cerebralartery and vertebrobasilar arterial systems in hyperlipidemia patients, and thus has some clinical value in determining changes in the brain of patients with high cholesterol levels and atherosclerosis.

关 键 词：高脂血症 经颅多普勒 脑血流动力学 

分 类 号：R589.2[医药卫生—内分泌]