前列腺增生症患者急性尿潴留发生的临床特点  

Clinical features of acute urine retention in patients with benign prostate hyperplasia

作　　者：张一川[1] 何乐业[1] 龙智[1] 孙晓辉[1] 王国民[1] 裴夏明[1] 钟狂飚[1] 叶啟发[2] 

机构地区：[1]中南大学湘雅三医院泌尿外科,长沙410013 [2]中南大学湘雅三医院卫生部移植医学工程技术研究中心,长沙410013

出　　处：《中南大学学报（医学版）》2012年第3期300-304,共5页Journal of Central South University ：Medical Science

摘　　要：目的:探讨前列腺增生症(BPH)患者发生急性尿潴留(AUR)的临床特点。方法:对548例BPH患者的临床资料进行回顾性研究,对有无AUR发生的两组患者临床相关参数进行统计学分析。结果:合并AUR的患者为164例(29.9%),不伴有AUR的患者为384例(70.1%)。两组患者的年龄、国际前列腺症状评分(IPSS)、最大尿流率(Qmax)、残余尿量、前列腺体积、移行区体积、总前列腺特异抗原(tPSA)、游离前列腺特异抗原(fPSA)、游总比及PSA密度差异均有统计学意义(P<0.05),而两组间的病程和移行区指数差异无统计学意义(P>0.05)。多因素logistic回归分析显示:IPSS、残余尿量、tPSA与AUR发生呈正相关,Qmax与AUR发生呈负相关。结论:发生AUR的BPH患者,其主要临床特点是年龄较大、IPSS值高、Qmax减少、前列腺体积增大、血清PSA升高及残余尿增多等,其中IPSS、残余尿量、tPSA及Qmax可作为预测AUR发生的主要临床指标。Objective： To explore the clinical features with benign prostate hyperplasia （BPH）. of acute urine retention （AUR） ocurring in patients Methods： Clinical data from 548 patients diagnosed with BPH were retrospectively studied, and the clinical parameters of these patients with or without AUR were analyzed by statistical methods. Results： Development of AUR was found in 164 patients （29.9%）. Patients＇ age, IPSS, maximum flow rate （Qmax）, residual urine volume, prostate volume, transition zone volume, prostate-specific antigen （PSA） densit）5 total PSA （tPSA） and free PSA （fPSA） including the ratio of free to total PSA（f/tPSA） were significantly different in the 2 groups （P〈0.05）, while there were no significant differences in the disease duration and transition zone index between the 2 groups （P〉0.05）. Multivariate logistic regression analysis showed that IPSS score, residual urine volume, tPSA, and Qmax were risk factors for predicting the development of AUR. Conclusion： BPH patient＇s age, IPSS, Qmaxw residual urine volume, prostate volume, transition zone volume, tPSA and fPSA, and PSA density all influence the occurrence of AUR, in which symptom severity, residual urine volume, total PSA and Qmax are the principal risk factors for prognosing AUR.

关 键 词：前列腺增生症 急性尿储留 危险因素 临床特点 

分 类 号：R697.3[医药卫生—泌尿科学]