心肌钙泵新的调节蛋白——sarcolipin研究进展  

Research progress of sarcolipin——a new regulatory protein of sarcoplasmic reticulum Ca^(2+) ATPase

作　　者：袁宝萍[1] 吕嵘[1] 顾燕频[1] 廖月玲[1] 卫洪昌[1] 

机构地区：[1]上海中医药大学基础医学院病理教研室,上海201203

出　　处：《中南大学学报（医学版）》2012年第3期316-319,共4页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(30973821);上海市基础研究重点项目(09JC1413300);上海市教委创新项目(10YZ52)~~

摘　　要：Sarcolipin(SLN)是新近发现存在于肌浆网中的小分子膜蛋白,分子质量为3 kD,由31个氨基酸构成,与受磷蛋白(phospholamban,PLB)属于同一蛋白家族。SLN可抑制肌浆网钙泵(sarcoplasmic reticulum Ca2+ATPase,SERCA)活性,降低其与Ca2+的亲和力,通过独立或与PLB协同作用影响SERCA活性,导致细胞内钙稳态失衡,降低心肌收缩力,从而发展为心衰。Sarcolipin （SLN） is a 3 kD membrane protein found in sarcoplasmic reticulum （SR）. It has 31 amino acid residues; SLN and phopholamban （PLB） are belong to the same protein famil）5 so they have similar physiological functions. SLN inhibits sarcoplasmic reticulum Ca2＋ ATPase （SERCA） activity and reduces its affinity of Ca2＋, resulting in dysfunction of myocardial contraction and heart failure. However, much remains to be elucidated. SLN independently or in conjunction with PLB affects SERCA activity, imbalancing intracellular calcium homeostasis, and reducing myocardial contractivity; these effects promote the development of heart failure.

关 键 词：SARCOLIPIN CA2+ 心衰 肌浆网钙泵 

分 类 号：R541.6[医药卫生—心血管疾病]