α-氰基丙烯酸酯类医用黏合剂的研究进展  

Advances in research on α-cyanoacrylate medical adhesives

作　　者：蔡大振[1,2] 徐亮[2] 孟庆国[1] 刘克良[2] 

机构地区：[1]烟台大学药学院,山东烟台264009 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《军事医学》2012年第3期238-240,F0003,共4页Military Medical Sciences

摘　　要：α-氰基丙烯酸酯类化合物可作为快速黏合剂,广泛应用于医疗领域,用于止血、伤口黏合、骨骼黏接、医疗栓塞、无痛绝育等。α-氰基丙烯酸酯化合物的合成路线各有优缺点,应结合结构特点进行选择。通过结构修饰可期望改善性能,扩大应用。本文综述了α-氰基丙烯酸酯类化合物的合成方法,结构修饰以及在医疗领域的研究进展,并展望在军事医学方面的应用前景。α-Cyanoacrylates are widely used as rapid tissue adhesives in the medical field,such as in hemostatic,wound bonding,bone bonding,medical embolism,painless sterilization.An appropriate synthetic route should be chosen for specific structure.Modifications can be made to improve the performance and to expand the range of application.This article reviewes the different synthetic routes,structure modifications and medical applications of α-cyanoacrylates adhesive.The prospect of their application in the military medical field is discussed.

关 键 词：Α-氰基丙烯酸酯 合成 结构修饰 临床医学 军事医学 

分 类 号：R318.08[医药卫生—生物医学工程]