双氢埃托啡的药物依赖性  

DRUG DEPENDENCE ON DIHYDROETORPHINE

作　　者：曹贵华[1] 陈泓[1] 蔡志基[1] 

机构地区：[1]北京医科大学中国药物依赖性研究所,北京100083

出　　处：《中国临床药理学杂志》1990年第1期54-59,共6页The Chinese Journal of Clinical Pharmacology

摘　　要：本文对新强效镇痛剂,双氢埃托啡的特殊毒理—药物依赖性进行了较系统的评价。采用小鼠跳跃实验和大鼠催促实验,对吗啡、双氢埃托啡、度冷丁和强痛定的身体依赖性进行评价并比较它们的依赖性潜力。本实验所测的药物依赖性潜力顺序是:吗啡>度冷丁>双氢埃托啡(或强痛定)。可以认为,双氢埃托啡的身体依赖性潜力较小。采用大鼠静脉自身给药法评价吗啡和双氢埃托啡的精神依赖性。实验中使用了两种给药程序,即1h给药法和20h给药法。结果表明,双氢埃托啡的精神依赖性潜力小于吗啡。Drug dependence on dihydroetorphine, a potent narcotic analgesic, was studied. The mouse jumping test and rat precipitation testwere used to evaluate the physical dependence potential of the drug andcompare with those of morphine, pethidine and AP-237. The order ofdependence potential on these drugs was as follows: morphine > pethidine> dihydroetorphine or AP-237. The psychic dependence potential of dihydroetorphine was studied,using iv self-administration experiments in rats and compared withmorphine. Two experimental procedures were adopted. i .e., 1h-session and20h-session procedures. Results indicated that dihydroetorphine is a positivereinforcer and its psychic dependence potential is weaker than that ofmorphine.

关 键 词：双氢埃托啡 药物依赖性 

分 类 号：R965.3[医药卫生—药理学]