Polycomb蛋白复合体对细胞衰老的表观遗传学调控  

Epigenetic Regulation Mediated by Polycomb on Cellular Senescence

作　　者：姚响芸[1] 王萌[1] 薛丽香[1] 

机构地区：[1]北京大学医学部生物化学与分子生物学系,北京100191

出　　处：《中国生物化学与分子生物学报》2012年第4期304-309,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.31071206);国家基础科学人才培养基金(No.J1030831/J0108)项目~~

摘　　要：细胞衰老在表观遗传学上的调控越来越受到人们的关注.Polycomb蛋白复合体(polycombgroup proteins)通过对组蛋白的修饰,尤其是甲基化修饰发挥对靶基因的沉默作用,并因此广泛参与到发育、增殖、分化以及肿瘤发生等重要生命过程.目前,有一系列的研究报道了polycomb的各组份参与了细胞衰老的调控.本文对polycomb发挥基因沉默作用机制的最新研究进展进行了归纳总结,并以衰老过程中的重要分子p16为重点,详细介绍了polycomb调节p16表达,影响细胞衰老进程的机制.研究表明,多种polycomb成员同时结合在p16INK4a基因座,它们的结合表现出相互依赖的同时又有各自的作用.这为进一步深入理解细胞衰老提供了表观遗传学的证据.The epigenetic regulation in cellular senescence receives more and more attention.Polycomb group proteins play key roles in gene silencing mediated by histone modification,especially methylation on histone and are invovled in development,proliferation,differeciation and tumour genesis etc.It was reported that many components of the polycomb were involved in the process of senescence.In this review,we summarized the mechanism of polycomb in gene silencing during the cellular senscence and presented the current experimental evidences related to polycomb and senescence,especially on the regulation of p16.Multiple polycomb are accumulated on p16INK4a loci simultaneously in the interdependent manner.They function as a whole complex while individually keep its own effect as well.We are trying to deepen the understanding the mechanism of cellular senescence from epigenetic point of view.

关 键 词：polycomb蛋白复合体 细胞衰老 表观遗传 P16 

分 类 号：Q71[生物学—分子生物学]