核素显像法估测不同条件下甲状腺模型体积计算方法的探讨  

Evaluation of thyroid volume estimation methods using radionuclide imaging under different condi-tions

作　　者：郭满涛[1] 杜补林[1] 李亚明[1] 尹雅芙[1] 周久贸[1] 陈松[1] 蒋宁一[2] 李德顺[1] 陈兴华[1] 

机构地区：[1]中国医科大学附属第一医院核医学科,沈阳110001 [2]中山医科大学附属第二医院核医学科

出　　处：《中华核医学与分子影像杂志》2012年第2期138-142,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：卫生部公益性卫生行业科研专项项目（200802028）

摘　　要：目的探讨在核素平面显像条件下，Allen法和椭球体法对估测不同体积、不同放射性活度甲状腺模型体积的影响。方法向甲状腺气球模型内注入不同体积和不同放射性活度的”Tc“0f溶液，并置入有机玻璃制成的颈部模型中，内充稻米模拟甲状腺颈部软组织吸收，进行核素平面显像。用Allen法和椭球体法在不同本底扣除水平下计算甲状腺模型体积，并将其与实际体积相比较，计算误差。结果在”rrc“昕溶液为7．4和18．5MBq条件下，当甲状腺模型体积为20～30“时，用Allen法，本底扣除20％，测量值误差最小，其相对误差均值为10．04％，误差范围为一19．23％～11．25％；当模型体积为40一80IIll时，用椭球体法，本底扣除20％，测量值误差最小，其相对误差均值为13．06％，误差范围为一21．41％～39．45％；当模型体积为90—110ml时，用Allen法，本底扣除20％，测量值误差最小，其相对误差均值为8．12％，误差范围为一11．05％一6．66％。在37．0和74．0MBq条件下，当甲状腺模型体积为20～30Tnl时，用Allen法，本底扣除20％，测量值误差最小，其相对误差均值为5．30％，误差范围为一1．25％～一11．73％；当模型体积为40～80ml时，用椭球体法，本底扣除20％，测量值误差最小，其相对误差均值为11．74％，误差范围为一30．36％一9．23％；当体积为90—110ml时，用Alien法，本底扣除15％，测量值误差最小，其相对误差均值为7．21％，误差范围为一13．76％～1．46％。结论用核素平面显像估测甲状腺模型体积时，体积大于90ml或小于40ml时用Allen法，本底扣除20％时（体积大于90ml、活度为37．0和74．0MBq时本底扣除15％），测得的体积误差较小；体积在40～80ml时，利用椭球体法，本底扣除20％，测得的体积误差较小。Objective To optimize the estimation of thyroid volume using Allen＇s and ellipsoid methods under different conditions including thyroid volume and radioactivity dosage. Methods Four sets of thyroid gland models were created. Ten different volumes of saline were injected to 10 balloons in each set. 99TcmO/ solutions with four different radioactivity doses were injected into each set of balloons. The thyroid models were placed into a plexiglasscontainer, which was filled with rice to simulate the neck soft tissue, and then underwent planar SPECT scans. Thyroid volumes were calculated with background correc- tion and compared with the true value to determine the measurement error. Results When the thyroid radi- oactivity was 7.4 and 18.5 MBq, and the thyroid volume ranged from 20 to 30 ml, the measurement error was the smallest （range： - 19.23% to 11.25%, mean： 10.04%） using Allen＇s method with 20% of background radioactivity deduction. When the thyroid volume was in the range of 40 to 80 ml, the measure- ment error was the smallest （ range ： - 21.41% to 39.45 %, mean ： 13.06% ） using ellipsoid method with 20% of background radioactivity deduction. When the thyroid volume was in the range of 90 to 110 ml, the measurement error was the smallest （ range ： - 11.05 % to 6.66%, mean： 8.12% ） using Allen＇ s method with 20% of background radioactivity deduction. When the thyroid radioactivity was 37.0 and 74.0 MBq, and the thyroid volume was in the range of 20 to 30 ml, the measurement error was smallest （range： -1.25% to -11.73%, mean： 5.30% ） using Allen＇s method with 20% of background radioactivity deduction.When the thyroid volume was in the range of 40 to 80 ml, the measurement error was the smallest （range： - 30.36% to 9.23%, mean： 11.74% ） using ellipsoid method with 20% of background radioactivity de- duction. When the thyroid volume was in the range of 90 to 110 ml, the measurement error was the smallest （range： -13.76% to 1.46%, mean： 7.21% ） using Allen＇s

关 键 词：甲状腺 模型 结构 放射性核素显像 体积 

分 类 号：R817.4[医药卫生—影像医学与核医学]