活化蛋白C抵抗与复发性流产关系的研究  

Study on Relationship of Activated Protein C Resistance and Recurrent Spontaneous Abortion

作　　者：董卫红[1] 魏文宁[2] 林美华[1] 

机构地区：[1]同济医科大学附属协和医院妇产科,武汉430022 [2]同济医科大学附属协和医院血液研究所,武汉430022

出　　处：《中华妇产科杂志》2000年第2期85-86,共2页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨活化蛋白C抵抗 (APC R)与复发性流产的关系。方法　用以活化部分凝血活酶时间 (APTT)为基础的APC R方法 ,检测 40例已产非孕妇女 (对照组 )、5 5例原因不明复发性流产患者 (实验组 )APC R的阳性率。结果　对照组APC R阳性率为 5 % ,实验组为 2 6 % ,两者比较 ,差异有极显著性 (P <0 .0 1)。仅有两次流产者和有 3次以上流产者的APC R阳性率分别为 2 3%和 2 9% ,两者比较 ,差异无显著性 (P >0 .0 5 ) ;晚期流产者的APC R阳性率为 38% ,明显高于早期流产的 12 %(P <0 .0 5 )。结论　APC R与复发性流产有一定联系 ,与晚期流产关系更密切 ,而与流产次数无关。Objective To investigate whether activated protein C resistance (APC R) is associated with recurrent spontaneous abortion. Methods APC R was detected by activated partial thromboplastin time (APTT) in the presence and absence of APC. Subjects included 40 nonpregnant parous women (control group) and 55 patients with recurrent spontaneous abortion. Results There was signficant difference for APC R between controls and the patients ( P <0.01). Among the study group,the prevalence of APC R positive rate had no relation to the numbers of abortion. The positive rate of APC R in patients with late abortion was significantly higher than those with only early abortion (38% and 12% respectively). Conclusion APC R is partly associated with recurrent spontaneous abortion, especially late abortion.It has no relation to the numbers of abortion.

关 键 词：流产 蛋白质C 抗药性 

分 类 号：R714.21[医药卫生—妇产科学]