体外电化学测试对镁合金体内降解行为的预测  

Indication of Electrochemical Measurements of Magnesium Alloys in vitro for Their Degradation Behavior in vivo

作　　者：王佳力[1] 唐键[1] 张鹏[1] 王珏[1] 李扬德 秦岭[1] 

机构地区：[1]中国科学院深圳先进技术研究院生物医学与健康工程研究所转化医学研究与发展中心,深圳518055 [2]东莞宜安科技股份有限公司,东莞523000

出　　处：《化学进展》2012年第4期598-605,共8页Progress in Chemistry

基　　金：广东省中国科学院全面战略合作项目(No.2010B090300076);省部产学研结合科技创新平台项目(No.2010B091000017);广东省产学研项目(No.2011A090100004);生物可降解镁合金及相关植入器件创新研发团队项目(No.201001C0104669453)资助

摘　　要：可生物降解镁合金因同时具有优良的生物相容性和力学性能,在生物医学界显示出其作为新型骨科内植入物的巨大潜在优势和市场前景。目前,作为制约镁合金医用产业化的关键因素,即过快的降解速率已经成为研究重点。本文回顾了体外电化学测试技术对镁合金抗腐蚀性能的研究,并分析了模拟腐蚀体系对镁合金腐蚀行为的影响;同时评估了电化学测试方法作为快速有效预测镁合金体内降解性能前期分析手段的可行性与局限性。最后,对如何发展更合理的体外电化学测试技术来预测镁合金体内降解提出了可能的解决方法及构思。As a novel orthopaedic implants in biomedical fields, biodegradable magnesium and its alloys have shown great potential and advantages due to their excellent biocompatibility and mechanical properties. The key factor to limit their further industrialization in the medical field is the rapid degradation behavior, which has become the focus of many researchers. In this paper, the research of corrosion resistance of magnesium-based alloys was summarized based on electrochemical measurements in vitro, and the effects of simulated corrosion system in vitro on corrosion behavior of magnesium and its alloys were also analyzed. Moreover, feasibility and limitation of the electrochemical methods as the fast and efficient indication of degradation behavior of magnesium alloys in vivo is evaluated. Finally, possible means and perspectives for more logic indication of degradation behavior of magnesium alloys in vivo are also proposed.

关 键 词：镁合金 电化学测试 内植入物 腐蚀 可生物降解 

分 类 号：TG178[金属学及工艺—金属表面处理] O646.6[金属学及工艺—金属学]