脑梗死患者血浆IL-11的检测及其临床意义  

Determination of Plasma Interleukin-11 Concentration in Patients with Cerebral Infarction and its Clinical Significance

作　　者：李剑[1] 朱颖[1] 吴琦[1] 

机构地区：[1]杭州市上城区中西医结合医院,310008

出　　处：《放射免疫学杂志》2012年第2期178-180,共3页Journal of Radioimmanology

摘　　要：目的:揭示脑梗死患者血浆IL-11浓度,分析其与预后的相关性。方法:对102例健康体检者和102例脑梗死患者,用ELISA检测血浆IL-11浓度,统计分析其水平改变及与预后的相关性。结果:脑梗死患者血浆IL-11浓度(22.6±9.8)pg/ml较健康体检者(11.2±3.6)pg/ml显著升高(P<0.01),与入院时美国国立卫生院神经功能缺损评分呈显著正相关(t=8.749,P<0.01),是脑梗死1年内预后不良(OR=1.308,95%CI=1.114～1.569,P<0.01)和死亡(OR=1.517,95%CI=1.218～1.881,P<0.01)的独立危险因素,可显著预测脑梗死1年内预后不良(曲线下面积=0.864,95%CI=0.827～0.918,P<0.01)和死亡(曲线下面积=0.889,95%CI=0.845～0.931,P<0.01)。结论:脑梗死后血浆IL-11显著升高,其水平检测可作为临床实用的标志物,有助于早期判断脑梗死预后。Objective To determine the level of the plasma interleukin-11 in patients with cerebral infarction and to correlate itslevel with disease outcome. Methods 102 healthy controls and 102 patients with cerebral infarction were included. Concentrations of the plasma interleukin-11 was measured with ELISA. Its association with disease outcome was analyzed statistically. Results The plasma interleukin-ll level （22.6 9.8） pg/ml in the patients was significantly higher than that （ 11.2 3.6） pg/ml in the healthy con- trois （P 〈 0.01 ）, was highly associated with National Institutes of Health Stroke Scale score （ t = 8. 749, P 〈 0.01 ）, was an inde- pendent variable predicting the poor functional outcome （ OR = 1. 308, 95% CI = 1.114 - 1. 569, P 〈 0.01 ） and mortality （ OR = 1. 517, 95% CI = 1. 218 - 1. 881, P 〈 0.01 ） 1 year after cerebral infarction and predicted the poor functional outcome （ Area under curve = 0.864,95% CI = 0.827-0.918, P 〈 0.01 ） and mortality （ Area under curve = 0. 889, 95% CI = 0. 845-0.931, P 〈 0.01 ） obviously. Conclusion Plasma interleukin-11 level increase after cerebral infarction. Its plasma level can be served as a useful clini- cal marker for evaluating the prognosis of cerebral infarction.

关 键 词：白介素-11 脑梗死 预后 

分 类 号：R512.62[医药卫生—内科学]