血清游离脂肪酸浓度和hs-CRP在老年DM2中的应用  

The Application of Serum Free Fatty Acids And hs-CRP Levels in Elder Type 2 Diabetics

作　　者：梁丽娟[1] 方亚奇[1] 苏丽蕴[1] 张敏霞[1] 

机构地区：[1]浙江省人民医院,310024

出　　处：《放射免疫学杂志》2012年第2期201-203,共3页Journal of Radioimmanology

摘　　要：目的:通过血清游离脂肪酸浓度(FFA)和超敏C反应蛋白(hs-CRP)水平的变化特征,探索血清FFA和hs-CRP与老年2型糖尿病(DM2)的关系。方法:应用免疫比浊法和生化法测定156名老年DM2患者和75名无DM2的健康对照组的FFA、hs-CRP、GLU、TG、TC、HDL-C和LDL-C的浓度,将测得的数据进行DM2组和健康对照组的对比分析。结果:DM2组患者血清FFA、hs-CRP、TG和LDL-C均比健康对照组高,差异有统计学意义(其中FFA和hs-CRP P<0.01,TG和LDL-C P<0.05);HDL-C低于健康对照组,差异有统计学意义(P<0.05);两组TC比较无统计学意义。结论:老年DM2患者血清FFA和ha-CRP浓度升高,FFA是反映糖代谢及脂代谢的灵敏指标。此外,可能参与患者代谢异常的发生、发展起重要作用。Objective Through the levels of serum free fatty acids（FFA） and hs-CRP changes character to explore the relation- ship of serum FFA and hs-CRP with DM2. Methods The levels of hs-CRP （with immuno-turbility method） and FFA,GLU,TG,TC, HDL-C, LDL-C （with biochemistry） in 156 DM2 patients and 75 healthy controls were determined . The date were analyzed with DM2 group and healthy group. Results FFA,hs-CRP,TG,TC,LDL-C in the diabetics were higher than those in healthy controls. The difference had statistic significance （ FFA and hs-CRP P 〈 0.01, TG and LDL-C P 〈 0.05 ） ; HDL-C lower than the healthy controls. The difference had statistic significance （P 〈 0.05）. The TC levels had no statistic significance between two groups. Conclusion Both FFA and hs-CRP concentrations increase in elder DM2 patients. FFA is a sensitive index of the glucose metabolism and lipid me- tabolism. Also, may play important role in development and progression of abnormal metabolism in elder type 2 diabetics.

关 键 词：游离脂肪酸 脂代谢 超敏C-反应蛋白 老年2型糖尿病 

分 类 号：R541.4[医药卫生—心血管疾病]