注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中的稳定性  

Stability and Compatibility of Lornoxicam and Morphine Hydrochloride in 0.9% Sodium Chloride Injection

作　　者：李鹏[1] 陈富超[1] 方宝霞[1] 胡敏[2] 姚园林[2] 

机构地区：[1]湖北医药学院附属东风医院药剂部,湖北十堰442008 [2]湖北医药学院药检学院,湖北十堰442000

出　　处：《医药导报》2012年第4期518-521,共4页Herald of Medicine

基　　金：十堰市科学技术研究与开发计划项目(2010st45)

摘　　要：目的考察注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中的稳定性。方法在室温(20±1)℃避光条件下,观察和检测注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中配伍液在72 h内的外观及pH变化,并用反相高效液相色谱法测定氯诺昔康与盐酸吗啡的含量。结果配伍液72 h内外观、pH及含量均无明显变化。结论室温条件下,注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中72 h内稳定。Objective To study the stability and compatibility of lornoxicam and morphine hydrochloride in 0.9% sodium chloride injection.Methods In 0.9% sodium chloride injection,the content change of lornoxicam and morphine hydrochloride was determined by reversed phased high performance liquid chromatogram under room temperature（20±1） ℃ within 72 h,and the appearance of the solution was observed and its pH value was determined.Results No significant differences were found in the content,color and pH value for the mixed solution at different time points within 72 h after mixing at room temperature.Conclusion The mixture of lornoxicam and morphine hydrochloride in 0.9% sodium chloride injection at ambient temperature was stable within 72 h.

关 键 词：氯诺昔康 吗啡 盐酸 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学]