耐亚胺培南鲍氏不动杆菌医院感染的临床分布及耐药性研究  

Clinical distribution of imipenem-resistant Acinetobacter baumannii infections and drug resistance

作　　者：黄晨[1] 诸林俏[1] 

机构地区：[1]温州医学院附属第二医院药剂科,浙江温州325027

出　　处：《中华医院感染学杂志》2012年第7期1466-1468,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解耐亚胺培南鲍氏不动杆菌(IRAB)医院感染的临床分布及耐药性,为临床合理使用抗菌药物提供依据。方法采用VITEK-32全自动细菌鉴定药敏系统及纸片扩散法(K-B法)测定鲍氏不动杆菌对15种抗菌药物的敏感性。结果 106株IRAB中,分离率居前3位的临床科室依次为ICU、呼吸内科、神经内科,分别占51.9%、12.3%、8.5%;临床标本中以呼吸道标本分离率最高,占68.9%;106株IRAB除对头孢哌酮/舒巴坦的耐药率<10.0%,对其他抗菌药物的耐药率均>57.6%。结论 IRAB医院感染和多药耐药性严重,出现了泛耐药菌株,医院应重视抗菌药物使用管理,尤其要关注泛耐药菌株的产生与流行。OBJECTIVE To explore the clinical distribution of imipenemresistant Acinetobacter baumannii （IRAB） infections and their drug resistance in order to provide reference for the rational use of antibiotics. METHODS Drug susceptibility of A. baumannii to 15 antibacterials was determined by VITEK32 fullautomatic bacterial identification susceptibility system and disk diffusion method（KB method）. RESULTS Of 106 strains of IRAB,the top 3 isolation rates were found in ICU （51.90//00）, department of respiratory medicine （12.3%）, and department of neurology （8.5 %）. The rate of the isolation from respiratory tract specimens was the highest （68.9 % ）. Most drug resistance rate of 106 strains of IRAB was higher than 57.6% except to cefoperazone/sulbactam, which was lower than 10. 0%. CONCLUSION Nosocomial infections caused by IRAB and multidrugresistance are serious. e Pandrug resistant strains have emerged, and the hospital should pay attention to the application of antibiotics, fo cusing on the emergence and prevalence of pandrug resistant strains.

关 键 词：耐亚胺培南鲍氏不动杆菌 医院感染 临床分布 耐药性 

分 类 号：R378[医药卫生—病原生物学]