正交试验法优化阿昔洛韦固体纳米粒的处方  

The Prescription of Optimizing Acyclovir Solid Nanoparticles with Orthogonal Test Method

作　　者：孟萍[1] 李佳琳[1] 金晓强[1] 刘春年[1] 颜承云[1] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《长春师范大学学报（人文社会科学版）》2012年第3期84-86,159,共4页Journal of Changchun Teachers Coliege

基　　金：黑龙江省自然科学基金项目(B201054)

摘　　要：采用正交试验法筛选阿昔洛韦固体脂质纳米粒最优处方。利用(W/O/W)复乳-超声法制备阿昔洛韦固体脂质纳米粒,以包封率为评价指标,采用L9(34)正交试验设计筛选出最优处方。单硬脂酸甘油酯用量1.5%、大豆卵磷脂用量0.4%、泊洛沙姆188浓度2%、油相与内水相体积比(Vo/V)i 6。正交试验优化阿昔洛韦固体纳米粒处方有效、可行。In this study, we screen the optimum prescription of Acyclovir solid lipid Nanoparticles with orthogonal test method. The Acyclovir solid lipid Nanoparticles is prepared by multiple-emulsion-ultrasound method, the entrapment efficiency is used as the evaluation index, and the optimum prescription is designed by L9 （34） orthogonal test. The amount of monostearate is 1.5%, the amount of soybean lecithin is 0.4%, the concentration of Poloxamer188 is 2%, and the phase volume ratio （Vo/Vi） is 6. The result show that the optimization of Acyclovir solid Nanoparticles with orthogonal test is effective and feasible.

关 键 词：阿昔洛韦 固体脂质纳米粒 复乳 正交试验 

分 类 号：R918[医药卫生—药学]