同型半胱氨酸与心脑血管疾病相关性研究进展  

Expression and significance of high mobility group A2 in pituitary adenomas

作　　者：刘君[1] 万云高[1] 孙志媛[1] 徐东[1] 

机构地区：[1]首都医科大学宣武医院心脏科,北京硕士研究生100053

出　　处：《中华临床医师杂志（电子版）》2012年第1期94-98,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：心脑血管疾病在世界范围内都是威胁人类健康的主要疾病之一。而动脉粥样硬化（atherosclerosis,AS）是此类疾病重要的病理基础。能导致AS的除了传统危险因素如吸烟、高血压、高脂血症等之外。Objective To study the relationship of the expressions of HMGA2 in pituitary adenomas and the relationships of the HMGA2 expressions with the invasiveness of pituitary adenomas was analyzed respectively.Methods The expressions of HMGA2 was determined by immunohistochemical technique and RT-PCR in 55 samples of pituitary adenomas.Results HMGA2 expressed in functional pituitary adenomas but not expressed in non-functional pituitary adenomas,expression in the invasive group was significantly higher than that of non-invasive group.Conclusions The high expression of HMGA2 plays an important role in the occurrence of functional pituitary adenomas and invasive in pituitary adenomas.

关 键 词：同型半胱氨酸 心脑血管疾病 疾病相关性 动脉粥样硬化 人类健康 世界范围 病理基础 危险因素 

分 类 号：R54[医药卫生—心血管疾病] R743[医药卫生—内科学]