RANTES与糖尿病及其血管并发症  

Clinicopathological significance of expression of c-Met in invasive breast ductal carcinoma

作　　者：张雪松 李会芳[1] 宋滇平[1] 

机构地区：[1]昆明医学院第一附属医院糖尿病科,650032

出　　处：《中华临床医师杂志（电子版）》2012年第1期99-101,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金资助(30760087);云南省自然科学基金(2004C0066M)

摘　　要：近来认为炎症因子和糖尿病及其并发症的发生发展密切相关。其中,C-C亚族趋化因子的作用日益受到关注。调节激活正常T细胞表达和分泌的细胞趋化因子（regulate upon activation normal T cell expressed and secreted,RANTES）属趋化性细胞因子C-C亚族家族成员,Objective To clarify the clinicopathological significance of expression of c-Met protein in invasive breast ductal carcinoma.Methods The expression of c-Met protein in the 100 samples was detected by non-biotin immunohistochemical method,the expression of positive cells for c-Met protein was evaluated,and its association with histological grade,lymphatic metastasis,TNM stage and prognosis was assessed.Results The expression of c-Met protein was positive in 43（43.0%）of 100 invasive breast ductal carcinomas.The positive expression of c-Met protein was significantly corresponding to lymph node metastasis（P=0.0001）,TNM stage（P=0.001）and prognosis（P=0.009）and but not to age（P=0.784）,tumor size（P=0.890）and histological grade（P=0.456）.But c-Met was not an independent prognostic factor（P=0.072）.Conclusions The expression of c-Met protein may play an important role with neoplastic progression in invasive breast ductal carcinoma.Expression of c-Met might be associated with aggressive tumor phenotype of invasive breast ductal carcinoma.The expression of c-Met may be a useful prognostic indicator.

关 键 词：血管并发症 RANTES 糖尿病 细胞趋化因子 趋化性细胞因子 C-C亚族 T细胞表达 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]