缺氧诱导因子在肺疾病中作用的研究进展  

Role of hypoxia-inducible factor in lung disease

作　　者：刘中洋[1] 伏丽晶[2] 刘静莉[1] 金发光[1] 

机构地区：[1]第四军医大学唐都医院呼吸内科,西安710038 [2]解放军第210医院干部病房三科,大连116021

出　　处：《国际呼吸杂志》2012年第7期552-556,共5页International Journal of Respiration

基　　金：军队“十一五”攻关项目（08G-102）;陕西省攻关项目（2008K1408）;陕西省攻关项目（2009K01-75）

摘　　要：缺氧诱导因子（HIF）是调节机体氧稳态的主要转录因子。在缺氧环境下，HIF调节许多目的基因的表达，这些基因表达的蛋白产物在血管再生、能量代谢、炎症反应和细胞存活方面起了重要作用。无论是在生理还是病理生理的情况下，肺部都可能出现局部或全肺的缺氧，此外，实验和临床数据均表明HIF与诸如肺损伤、肺动脉高压、肺肿瘤等肺疾病的发病机制有关。因此，研究HIF在肺疾病中的作用有非常重大的意义。Hypoxia-inducible factor（HIF） is a transcription factor that functions as a master regulator of oxygen homeostasis. Under hypoxie condition, HIF has been shown to regulate the expression of dozens of target genes, the protein products of which play important roles in angiogenesis, energy metabolism, inflammation, and cell survival. There are numerous instance, in both physiologic and pathophySiologic conditions, during which the lung experiences localized or global hypoxia. In addition, HIF has been implicated in the pathogenesis of lung diseases such as lung injury, pulmonary hypertention and lung cancer based on both experimental and clinical data. Therefore, analyzing the role of HIF in lung diseases is of momentous significance.

关 键 词：缺氧诱导因子 肺疾病 肺损伤 肺动脉高压 肺肿瘤 

分 类 号：R563.9[医药卫生—呼吸系统]