莉芙敏治疗妇女围绝经期综合征的疗效研究  

The Clinical Analysis of Treating Perimenopause Syndrome with Remifemin

作　　者：曹杰[1] 赵纯全[1] 

机构地区：[1]重庆医科大学附属第一医院妇产科,重庆市400016

出　　处：《临床合理用药杂志》2012年第9期17-20,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨莉芙敏治疗妇女围绝经期综合征的疗效及安全性。方法选取我科门诊就诊的符合围绝经期综合征诊断标准的150例患者随机分配入两组:莉芙敏组(治疗组)100例,给予莉芙敏口服治疗,1片/次,2次/d,连续服用3个月;维生素B6组(对照组)50例,给予维生素B6口服治疗,1片/次,1次/d,连续服用3个月。经检查无子宫、卵巢的恶性病变,子宫内膜<5mm,乳腺检查无异常。治疗前后填写Kupperman Index(KMI)和Men-opause Rating Scale(MRS)量表并评分,对比治疗前后围绝经期综合征妇女的临床症状、性激素水平〔促卵泡生成素(FSH)、黄体生成素(LH)、雌二醇(E2)〕、肝肾功能〔丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肌酐(Cr)〕、脂代谢〔三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)〕及空腹血糖(FBG)的变化,同时行妇科B超、乳腺B超、宫颈细胞学涂片及乳房触诊等检查及观察药物不良反应。结果应用莉芙敏治疗3个月后,围绝经期综合征患者的症状明显缓解,部分患者潮热、多汗、睡眠障碍消失,总有效率为92.3%;用药前后KMI及MRS量表评分差异显著,与对照组比较及治疗前后比较差异有统计学意义(P<0.001);治疗组用药前后血FSH、LH、E2水平无明显变化,差异无统计学意义(P>0.05);用药后FBG与用药前相比无明显变化,差异无统计学意义(P>0.05);脂代谢中TG、TC含量较用药前降低,差异有统计学意义(P<0.05),HDL较用药前升高,LDL较用药前降低,差异有统计学意义(P<0.05);用药前后患者的肝肾功能无明显变化(P>0.05);用药前后的宫颈涂片均未发现有不典型增生细胞及癌细胞;用药过程中6例患者在治疗1月后出现胃部不适,4例在治疗2个月后出现乳房胀痛,继续服药后症状消失,仅1例在治疗1个月后头痛,未出现异常阴道流血、腹痛、水肿、乳房包块等严重不良反应。结论莉芙敏治疗围绝经Objective To investigate the clinical efficacy and safe of Remifemin in treating perimenopause syndrome.Methods 150 perimenopausal women with perimenopause syndrome from outpatient were divided into 2 groups randomly：100 cases in Remifemin group（therapy group） were treated with Remifemin tablets（one tablet each time,two times a day）orally for 3 months;50 cases in control group were treated with vitamin B6 tablets（one tablet each time,one time a day）orally for 3 months;None of them had evidences of ovarian or uterine malignant tumors,endometrial thickness was5mm,breast physical examination was normal.During the medication,the females fill in diaries（fill in the scores of KMI and MRS）.Comparing the variance of theirs clinical symptoms,physical signs,the sexual hormone（follicle stimulating hormone,luteinizing hormone,estradiol）,liver and kidney function（alanine aminotransferase,aspartate aminotransferase,creatinine）,lipid metabolism（triglyeride,total cholesterol,high-density lipoprotein,low-density lipoprotein）and fasting blood glucose to explore the clinical curative effects.Testing the variance of B-ultrasound in pelvic cavity,B-ultrasound in breast,the palpation of breast and cervical smear and observing the poisonous side effects and adverse effects to evaluate the safe of Remifemin.Results Three months after Remifemin treatment,symptoms of perimenopause syndrome were significantly relieved,sweat,hot flash and sleep disorders disappeared in some of these patients,clinical total effective rate reaches 92.3 percent.Clinical trials show that the scores of KMI and MRS have both greatly statistical significance as compared with control group and the values before treatment（P0.001）;In therapy group,the levels of females serum FSH,LH,E2 after the treatment have no greatly changes compared with those before the treatment,the difference has no statistical significance（P0.05）;The levels of fasting blood glucose after the treatment have no greatly changes compared with those before the

关 键 词：莉芙敏 围绝经期综合征 黑升麻 

分 类 号：R711.75[医药卫生—妇产科学]