当归破壁粉粒补血作用及急性毒性实验研究  

A study on the effect of the blood enrichment and acute toxicity of cell-wall broken powder of Angelica sinensis

作　　者：闵欢[1,2] 成金乐 陈健文[3] 徐吉银 邓雯 刘培庆[3] 黄芝瑛[3] 

机构地区：[1]中山市中智药业集团有限公司,广东中山528437 [2]广州中医药大学中药资源科学与工程研究中心,广东广州510006 [3]中山大学药学院,广东广州510080

出　　处：《广东药学院学报》2012年第1期73-75,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省粤港关键领域重点突破招标项目(20080106-2);广东省科技计划项目(粤科计字[2008]72号);中山市科技强企支撑计划项目(20092A113)

摘　　要：目的探讨当归破壁粉的补血作用及急性毒性作用。方法建立失血性贫血小鼠模型,以白细胞(WBC)、红细胞(RBC)、血红蛋白(Hb)、血小板(PLT)等血常规指标衡量当归破壁粉粒对贫血的治疗作用,并以当归破壁粉粒及其饮片80 g/kg给小鼠灌胃后7 d,观察其对小鼠的急性毒性。结果当归破壁粉粒能明显改善小鼠贫血指标,且未观察到当归破壁粉粒及其饮片的急性毒性发生。结论当归破壁粉粒具有补血作用且无急性毒性作用。Objective To study the effect of the blood enrichment and acute toxicity of cell-wall broken powder of Angelica sinensis.Methods Establish a hemorrhagic anemia mouse model and measure the effect of the blood enrichment of cell-wall broken powder of Angelica sinensis by WBC,RBC,Hb,PLT and other blood indicators.Then 80 g dried medicinal herbs/kg of cell-wall broken powder and decoction pieces of Angelica sinensis were administrated in mice,and these acute toxic reactions were observed continuously for 7 days.Results Cell-wall broken powder of Angelica sinensis obviously improved blood indicators.No toxic reactions were observed on cell-wall broken powder and decoction pieces of Angelica sinensis.Conclusion Cell-wall broken powder of Angelica sinensis has the effect of the blood enrichment but no toxic reaction.

关 键 词：当归饮片 破壁粉粒 补血作用 急性毒性 

分 类 号：R285.5[医药卫生—中药学]