Comparison of the effects of carbamyl-β-methylcholine chloride ad ministered by intravenous,intramuscular and intra-acupuncture point injections  

作　　者：王玉敏 高俊虹 逯波 彭娟 范斌 崔晶晶 王洪新 马琰岩 喻晓春 

机构地区：[1]Department of Physiology,Experimental Research Center,China Academy of Chinese Medical Sciences [2]Department of Physiology,Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences [3]Department of Pharmacology,Liaoning Medical College

出　　处：《Journal of Traditional Chinese Medicine》2012年第1期93-98,共6页中医杂志（英文版）

基　　金：Supported by Beijing Natural Science Foundation Grant(grant number 7072053);the National Basic Research Pro-gram of China (973 Program) of China Grant(2006CB504506);the National Natural Science Foundationof China (NSFC) Grants (30873295 and 30801485);the Business fees of China academy of Chinese Medical Sciences for independent Topics of Basic Researchers (ZZ2007001)

摘　　要：OBJECTIVE:To compare the effects of carbamylβ-methylcholine chloride(CMCC) administered by intra-acupuncture point injection(IAI),intramuscular injection(IMI),and intravenous injection(IVI),and to analyze the mechanisms.METHODS:In the IAI group,CMCC was injected into the Zusanli acupoint(ST 36) immediately after 30-min stimulation by electro-acupuncture(EA) at the acupoints,and into the femoral vein and skeletal muscle in IVI and IMI groups,respectively.Intra-gastric pressure was detected.The plasma concentration of CMCC was measured at various times.RESULTS:The gastric effect of CMCC in the IVI group was enhanced and attenuated more rapidly than in the other groups.In the IAI group,this effect was significantly stronger than that in the IMI group at 2 min and 15 min,but not significantly different between the two groups at 5 min and 30 min.Plasma concentration of CMCC in the IAI group was similar to that in the IVI group at 2 min,but higher than that in the IMI group.The concentration in the IAI group was higher than that in the IV group and similar to that in the IMI group at 5,15 and 30 min,indicating rapid increase and slower reduction of the plasma concentration of the drug in the IAI group.There was a positive correlation between the plasma concentration of CMCC and intragastric pressure in all groups.CONCLUSION:The effect of IAI with CMCC was stronger than that of IMI and longer-lasting than that of IVI,which correlated with the blood concentration of CMCC.OBJECTIVE：To compare the effects of carbamylβ-methylcholine chloride（CMCC） administered by intra-acupuncture point injection（IAI）,intramuscular injection（IMI）,and intravenous injection（IVI）,and to analyze the mechanisms.METHODS：In the IAI group,CMCC was injected into the Zusanli acupoint（ST 36） immediately after 30-min stimulation by electro-acupuncture（EA） at the acupoints,and into the femoral vein and skeletal muscle in IVI and IMI groups,respectively.Intra-gastric pressure was detected.The plasma concentration of CMCC was measured at various times.RESULTS：The gastric effect of CMCC in the IVI group was enhanced and attenuated more rapidly than in the other groups.In the IAI group,this effect was significantly stronger than that in the IMI group at 2 min and 15 min,but not significantly different between the two groups at 5 min and 30 min.Plasma concentration of CMCC in the IAI group was similar to that in the IVI group at 2 min,but higher than that in the IMI group.The concentration in the IAI group was higher than that in the IV group and similar to that in the IMI group at 5,15 and 30 min,indicating rapid increase and slower reduction of the plasma concentration of the drug in the IAI group.There was a positive correlation between the plasma concentration of CMCC and intragastric pressure in all groups.CONCLUSION：The effect of IAI with CMCC was stronger than that of IMI and longer-lasting than that of IVI,which correlated with the blood concentration of CMCC.

关 键 词：ACUPUNCTURE Intra-acupuncture point injection Synergistic effect Plasma concentration 

分 类 号：R245[医药卫生—针灸推拿学]